Human hcxä BAFF

Product Code: 8001B
Pack Size: 2 ug
Form: human recombinant protein
Product Type: Protein

Supplier: Symansis
Product Category: Miscellaneous > Proteins

Further information: Symansis is the only company offering a large range of human cell expressed (hcx) recombinant proteins for life science researchers. Human cell expressed (hcx) recombinant human proteins have human post-translational modifications that can affect immunogenicity and stability. BAFF is found in two forms, a type II membrane protein or a proteolytically derived soluble form (as offered by Apollo). BAFF functions predominantly as a B cell survival factor and specifically promotes the proliferation and survival of activated B cells by inducing expression of pro-survival oncogenes. BAFF is expressed by T cells, dendritic cells, macrophages and neutrophils. BAFF binds to three different receptors: the transmembrane activator and calcium modulator cyclophilin ligand intercator (TACI), B cell maturation antigen (BCMA) and BAFF receptor (BAFFR). These are expressed on B cells and the BAFFR is also expressed on T cells suggesting BAFF may play a role in T cell activation.

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