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AdipoGen Life Sciences

anti-LAG-3 (human) mAb (blocking) (17B4) (preservative free)

Product Code:
 
AG-20B-0012PF
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
17B4
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Functional Study
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
 

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CodeSizePrice
AG-20B-0012PF-C100100 ug£361.00
Quantity:
AG-20B-0012PF-C500500 ug£1,411.00
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Further Information

Alternate Names/Synonyms:
Lymphocyte Activation Gene-3; FDC Protein; CD223
Concentration:
1mg/ml
EClass:
32160000
Endotoxin:
<0.001EU/µg purified protein or <1EU/mg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. In PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.
Long Description:
Monoclonal Antibody. Recognizes human LAG-3. Isotype: Mouse IgG1. Clone: 17B4. Applications: FACS, FUNC (Blocking), ICC, IHC, IP, WB. Liquid. In PBS. Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
NCBI, Uniprot Number:
P18627
Package Type:
Plastic Vial
Product Description:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes human LAG-3.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens: E. Baixeras, et al.; J. Exp. Med. 176, 327 (1992) | Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand: B. Huard, et al.; Immunogenetics 39, 213 (1994) | Characterization of the major histocompatibility complex class II binding site on LAG-3 protein: B. Huard, et al.; PNAS 94, 5744 (1997) | CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling: S. Hannier, et al.; J. Immunol. 161, 4058 (1998) | T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts: C.E. Demeure, et al.; Eur. J. Cancer 37, 1709 (2001) | Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway: E.D. Carlo, et al.; J. Pathol. 205, 82 (2005) | The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells: L. Macon-Lemaitre & F. Triebel; Immunology 115, 170 (2005) | A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) | Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells: J. Bayry, et al.; J. Immunol. 178, 4184 (2007) | Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation: C. Casati, et al.; J. Immunol. 180, 3782 (2008) | Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia: M. Shapiro, et al.; Haematologica 102, 874 (2017) | Targeting LAG-3 and PD-1 to enhance T cell activation by antigen-presenting cells: F.S. Lichtenegger, et al.; Front. Immunol. 9, 385 (2018) | Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer: G. Zhou, et al.; Oncoimmunology 7, e1448332 (2018) | Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT: E. Zaghi, et al.; JCI Insight 6, e146973 (2021)