UK Distributor of Adipogen Life Sciences - Leading Supplier of Innovative Research Reagents for Inflammation & Immune Responses

Adipogen Life Sciences

AdipoGen Life Sciences, Inc. (AGLS) is a leading company in the arena of the life science research products market. A highly skilled team of individuals manufactures specialised and comprehensive product portfolios comprising proteins, antibodies (functional monoclonal antibodies and non-animal derived antibodies), ELISA kits, and small molecules in fast-growing, new and innovative research areas focusing on inflammation & immune responses.

These scientific areas include:

See the other brands supplied by AdipoGen Life Sciences here

Inflammasomes & innate immunity

AdipoGen Life Sciences is an expert in inflammasome research. Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation.

The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukin-1β (IL-1β) from cells of the innate immune system.

Beneficial inflammatory responses arise by maintaining homeostatic tissue function (detection and repair of tissue damages after trauma or pathogen invasion). Among the harmful inflammatory responses are particle-induced sterile inflammation, caused by host-derived particles such as monosodium urate (MSU) crystals, as well as environmental and industrial particles such as asbestos, silica and metallic nanoparticles.

Accumulating evidence also implicates inflammasome activity in numerous other diseases, including cancer and the development of metabolic diseases (like type 2 diabetes, atherosclerosis), some neurodegenerative diseases (like Alzheimer, Prion, Parkinson), autoimmune diseases (such as multiple sclerosis) and inflammatory bowel diseases.

AdipoGen provides a large selection of research reagents targeted to the various components of the inflammasome, thanks to a long-term collaboration with the Professor Jurg Tschopp group - the team who discovered the inflammasome in 2002.

Read more about inflammasomes on Inflammasomes Insights, and Inflammasomes and Gasdermin D Signaling Pathways.

AdipoGen also provides a large selection of research reagents targeted to the various components of the immune system. The innate immune system plays an essential role in the host’s first line of defence against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).

To view the products AdipoGen Life Sciences has to offer relating to inflammasomes & innate immunity please click on the following links:

Take a look at their inflammasomes & innate immunity reagents brochures and posters for more information:

B & T cells immune regulation

Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving the system’s natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers.  AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including:

Read more on Immune Checkpoints Insights or have a look at their brochures and wallcharts:


AdipoGen Life Sciences offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes a broad range of IL-33 reagents, the best inflammasomes research reagents to study the activation of neuroinflammation, posttranslational microtubule-specific antibodies, biologically active Notch ligands, unique progranulin ELISA Kits and proteins, a broad range of immunometabolism reagents, biologically active Netrin-1 for axon outgrowth studies, many Neurochemicals, a selected range of neuronal dyes and stain, and many other reagents.

Read more on progranulin insights or have a look at their brochures and wallcharts:

Obesity and Metabolism

AdipoGen Life Sciences provides a wide range of products for obesity and metabolism research, including adipokine ELISA kits, obesity-related proteins & antibodies, Fibroblast Growth Factor products, PPARƳ reagents, metabolic research modulators and much more. Click one of the links below to view AdipoGen’s metabolism and obesity-related products:

Obesity is at an all-time high and numbers just keep growing, with it increasing the chances of developing type 2 diabetes, heart disease and cancer, it is not a surprise that obesity and metabolism are hot topics for research. It is becoming evident that these diseases are linked to unbalanced nutrition together with closely related inflammatory processes.

To facilitate improved treatment of the diseases, it is necessary to understand the cross-talk between the hormones and cytokines secreted from fat cells and immune cells and to understand the principles of the specific binding of ligands to the receptors.

For more information on obesity and metabolism research please feel free to take a look at the brochures below:


AdipoGen Life Sciences is a leading manufacturer of COVID-19 related products with an ongoing pipeline for detection of soluble ACE2, antibodies against SARS-CoV-2 and a HTS detection kit for the determination of SARS-CoV-2 blocking reagents. Read more about the latest insights & products for SARS-CoV-2/COVID-19 research here or browse the available products:

Latest Insights on COVID-19 Research

Small Molecules

AdipoGen Life Sciences is a manufacturer of synthetic small molecules, unique natural products and rare antibiotics.

Please click on the links below and look through AdipoGen’s range of synthetic small molecules available:

Their small molecules range include products for many different research areas, including; inflammation, metabolic research, cancer and immunology. Find more information on the range of products offered by browsing the brochures and flyers below:

Other Brands Supplied By AdipoGen

AdipoGen is also the official supplier for several other brands which provide products for a number of other research areas including; cancer, neurodegeneration and immunology. Please click on the links below to find out more about the following brands:

  • Ancell - High-quality immunology reagents
  • BioActs - Biochemical labelling, cell analysis, in vivo imaging and nucleic acid labelling dyes
  • BioViotica - Rare active natural products
  • Chemodex - Fluorescent probes, stains / labels / dyes, metabolites and small molecules
  • Chimerigen - Unique immunoglobulin-based chimeric fusion proteins
  • Innaxon - The Experts for TLR agonists and antagonists
  • JaiCa - Unique oxidative stress markers
  • RevMAb - Advanced Recombinant Antibodies, Improved IHC Detection
  • South Bay Bio - Proteasomes, UB (Ubiquitin Proteasome) Conjugation and Deconjugation, C-Terminal Derivatives and TR-FRET
  • Synkinase - Small Molecules and Kinase Inhibitors

Blog posts

New B7 Family Immune Checkpoint Proteins

Recently 5 new B7 family ligands, B7-H3, B7-H4, B7-H5, B7-H6 & B7-H7, were identified, all of them possibly of high interest in immunotherapy research.


HVEM – BTLA – LIGHT – CD160 Network

The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.


OX40 – OX40L Pathway

OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.


TIGIT – CD155 – CD112 – CD226 Network

Tumour cells exploit the dominance of the inhibitory TIGIT pathway to avoid immune-mediated destruction.


LAG-3 – Major Histocompatibility Complex (MHC) – T Cell Receptor (TCR) Pathway

Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.


CTLA-4 [CD152] – CD80 – CD86 – CD28 Network

Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.


Butyrophilin-like Proteins & Other Immune Checkpoint Proteins

Human Ig superfamily receptor proteins of the structural & functional diverse BTN & BTNL families are potentially important immune modulators.


CD40 – CD40L Pathway

CD40 is a member of the TNF receptor family expressed by APCs and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells.


GITR – GITRL Pathway

Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.


CD137 – CD137L Pathway

CD137 is an activating receptor binding to CD137L, expressed on natural killer (NK) cells & T cells, therefore triggering innate & adaptive immunity.


TIM-3 – Galectin-9 Pathway

T cell immunoglobulin & mucin-3 (TIM-3; HAVcr-2) is an immune checkpoint receptor involved in the suppression of both innate & adaptive immune cells.


ICOS [CD278] – ICOSL [CD275] Pathway

ICOS/ICOSL signalling leads to the activation, proliferation and survival of cytotoxic T cells, as well as the survival of memory T cells.


PD-1 [CD279]/PD-L1 [CD274] Pathway

The PD-1/PD-L1 or PD-L2 signalling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production.


Proteins with Enhanced Activity & Stability

AdipoGen Life Sciences specialises in the development of recombinant proteins that show enhanced activity and stability, produced in mammalian cells.


Neutralising Antibody Detection Kits for SARS-CoV-2 Variants

List of AdipoGen Life Sciences' neutralising antibody detection kits for SARS-CoV-2 variants


Validated Recombinant Proteins for ACE2 & COVID-19 Research

List of AdipoGen Life Sciences' validated recombinant proteins for ACE2 & COVID-19 research



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