UK Distributor of Adipogen Life Sciences - Leading Supplier of Innovative Research Reagents for Inflammation & Immune Responses

Adipogen Life Sciences

AdipoGen Life Sciences, Inc. (AGLS) is a leading company in the arena of the life science research products market. A highly skilled team of individuals manufactures specialised and comprehensive product portfolios comprising proteins, antibodies (functional monoclonal antibodies and non-animal derived antibodies), ELISA kits, and small molecules in fast-growing, new and innovative research areas focusing on inflammation & immune responses.

These scientific areas include:

See the other brands supplied by AdipoGen Life Sciences here

Inflammasomes & innate immunity

AdipoGen Life Sciences is an expert in inflammasome research. Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation.

The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukin-1β (IL-1β) from cells of the innate immune system.

Beneficial inflammatory responses arise by maintaining homeostatic tissue function (detection and repair of tissue damages after trauma or pathogen invasion). Among the harmful inflammatory responses are particle-induced sterile inflammation, caused by host-derived particles such as monosodium urate (MSU) crystals, as well as environmental and industrial particles such as asbestos, silica and metallic nanoparticles.

Accumulating evidence also implicates inflammasome activity in numerous other diseases, including cancer and the development of metabolic diseases (like type 2 diabetes, atherosclerosis), some neurodegenerative diseases (like Alzheimer, Prion, Parkinson), autoimmune diseases (such as multiple sclerosis) and inflammatory bowel diseases.

AdipoGen provides a large selection of research reagents targeted to the various components of the inflammasome, thanks to a long-term collaboration with the Professor Jurg Tschopp group - the team who discovered the inflammasome in 2002.

Read more about inflammasomes on Inflammasomes Insights, and Inflammasomes and Gasdermin D Signaling Pathways.

AdipoGen also provides a large selection of research reagents targeted to the various components of the immune system. The innate immune system plays an essential role in the host’s first line of defence against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).

To view the products AdipoGen Life Sciences has to offer relating to inflammasomes & innate immunity please click on the following links:

Take a look at their inflammasomes & innate immunity reagents brochures and posters for more information:

B & T cells immune regulation

Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving the system’s natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers.  AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including:

Read more on Immune Checkpoints Insights or have a look at their brochures and wallcharts:

Neuroinflammation

AdipoGen Life Sciences offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes a broad range of IL-33 reagents, the best inflammasomes research reagents to study the activation of neuroinflammation, posttranslational microtubule-specific antibodies, biologically active Notch ligands, unique progranulin ELISA Kits and proteins, a broad range of immunometabolism reagents, biologically active Netrin-1 for axon outgrowth studies, many Neurochemicals, a selected range of neuronal dyes and stain, and many other reagents.

Read more on progranulin insights or have a look at their brochures and wallcharts:

Obesity and Metabolism

AdipoGen Life Sciences provides a wide range of products for obesity and metabolism research, including adipokine ELISA kits, obesity-related proteins & antibodies, Fibroblast Growth Factor products, PPARƳ reagents, metabolic research modulators and much more. Click one of the links below to view AdipoGen’s metabolism and obesity-related products:

Obesity is at an all-time high and numbers just keep growing, with it increasing the chances of developing type 2 diabetes, heart disease and cancer, it is not a surprise that obesity and metabolism are hot topics for research. It is becoming evident that these diseases are linked to unbalanced nutrition together with closely related inflammatory processes.

To facilitate improved treatment of the diseases, it is necessary to understand the cross-talk between the hormones and cytokines secreted from fat cells and immune cells and to understand the principles of the specific binding of ligands to the receptors.

For more information on obesity and metabolism research please feel free to take a look at the brochures below:

COVID-19

AdipoGen Life Sciences is a leading manufacturer of COVID-19 related products with an ongoing pipeline for detection of soluble ACE2, antibodies against SARS-CoV-2 and a HTS detection kit for the determination of SARS-CoV-2 blocking reagents. Read more about the latest insights & products for SARS-CoV-2/COVID-19 research here or browse the available products:

Latest Insights on COVID-19 Research

Small Molecules

AdipoGen Life Sciences is a manufacturer of synthetic small molecules, unique natural products and rare antibiotics.

Please click on the links below and look through AdipoGen’s range of synthetic small molecules available:

Their small molecules range include products for many different research areas, including; inflammation, metabolic research, cancer and immunology. Find more information on the range of products offered by browsing the brochures and flyers below:

Other Brands Supplied By AdipoGen

AdipoGen is also the official supplier for several other brands which provide products for a number of other research areas including; cancer, neurodegeneration and immunology. Please click on the links below to find out more about the following brands:

  • Ancell - High-quality immunology reagents
  • BioActs - Biochemical labelling, cell analysis, in vivo imaging and nucleic acid labelling dyes
  • BioViotica - Rare active natural products
  • Chemodex - Fluorescent probes, stains / labels / dyes, metabolites and small molecules
  • Chimerigen - Unique immunoglobulin-based chimeric fusion proteins
  • Innaxon - The Experts for TLR agonists and antagonists
  • JaiCa - Unique oxidative stress markers
  • RevMAb - Advanced Recombinant Antibodies, Improved IHC Detection
  • South Bay Bio - Proteasomes, UB (Ubiquitin Proteasome) Conjugation and Deconjugation, C-Terminal Derivatives and TR-FRET
  • Synkinase - Small Molecules and Kinase Inhibitors

Blog posts

SARS-Cov-2 Neutralising Antibody Kits

When someone contracts COVID-19, the host’s immune response can be measured by the presence of neutralising antibodies. Neutralising antibodies prev…

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Flow Cytometry-Competent Human ACE2 Monoclonal Antibodies

AdipoGen Life Sciences' anti-ACE2 (human), mAb (AC18F) (Prod. No. AG-20A-0032) is a monoclonal antibody clone that recognizes human ACE2 and works s…

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New & Unique SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit

AdipoGen Life Sciences has developed a sensitive and specific SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit (Prod. No. AG-45B-0020) that can…

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Cytokine Storm and Severity of COVID-19

The most critically ill COVID-19 patients are known to undergo a cytokine storm leading to poor prognosis and need of urgent anti-inflammatory treatme…

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Antiviral Compounds - Potential Small Molecule Therapeutics Against COVID-19

There are no approved drugs to treat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that causes coronavirus disease 2019 (…

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UNIQUE Human ACE2 Monoclonal Blocking Antibody

AdipoGen Life Sciences' anti-ACE2 (human), mAb (blocking) (AC384) (preservative free) (Prod. No. AG-20A-0037PF) is a monoclonal antibody that recogn…

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New SARS-CoV-2 Inhibitor Screening Set

AdipoGen Life Sciences' SARS-CoV-2 Inhibitor Screening Set (Prod. No. AG-44B-0007) has been developed as a High Throughput Screening (HTS) detection…

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COVID-19 Diagnostics

As the world is struggling to contain the novel coronavirus (COVID-19) outbreak, healthcare infrastructure and testing capacity have emerged as major…

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Biological Therapeutic Strategies against SARS-CoV-2 and COVID-19

18 years ago the SARS-CoV lead to respiratory diseases in infected people. To date there are no effective vaccines against any type of the coronavirus…

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ACE2 & Functional Receptor for SARS Coronaviruses

Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane metallocarboxypeptidase within the renin-angiotensin system (RAS), which plays a key…

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Latest Insights & Products for SARS-CoV-2/COVID-19 Research

Coronaviruses (CoVs) - SARS-CoV & SARS-CoV-2 [2019-nCoV] Coronaviruses (CoVs) are enveloped non-segmented positive-sense RNA viruses infecting hu…

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Protective role for IL-36 cytokines in obesity and metabolic disease

Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin i…

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Stress granules inhibit NLRP3 inflammasome activation by sequestering the helicase DDX3X

Inflammasomes are large multimolecular complexes involved in innate immune response and driving cell fate towards cell death, called pyroptosis. Stres…

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The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1

Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Vi…

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OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating…

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Extracellular Vesicles Containing eNAMPT Extend Lifespan

A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels…

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