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Antibiotics

Rare Antibiotics

Rare Antibiotics

Cancer Research Modulators| Antiviral and Anti-inflammatory compounds| Neuroscience Research Reagents

Unique Natural Products & Rare Antibiotics

Unique Natural Products & Rare Antibiotics

From Bacterial, Fungal, Marine & Plant Sources

Unique Natural Products & Rare Antibiotics

Unique Natural Products & Rare Antibiotics

Discovered by the Nobel Prize Awarded Kitasato Institute for Life Sciences.

 

Antibody Tools

Functional Antibodies: Blocking, Neutralizing, Activation & Depletion

Functional Antibodies: Blocking, Neutralizing, Activation & Depletion

Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™))are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Functional grade antibodies are available free of preservatives and tested for low endotoxin content and may be used for activation, neutralizing or blocking studies, both in vitro or in vivo.

 

Apoptosis

Trail & Trail Receptors: Effectors of Apoptotic Signaling

Trail & Trail Receptors: Effectors of Apoptotic Signaling

TRAIL Ligand for in vivo Research| TRAIL-R1 specific Ligand| TRAIL Receptors Antibodies for IHC

 

Autophagy

Modulators of Autophagy Signalling

Modulators of Autophagy Signalling

Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins through a lysosome-dependent degradation pathway.

 

Biochemicals

Small Molecules, Rare Antibiotics & Unique Natural Products

Small Molecules, Rare Antibiotics & Unique Natural Products

AdipoChem™ is the Biochemicals business division of Adipogen International which was started by former ALEXIS Corporation scientists, manufacturing small molecules, rare antibiotics and natural products.

 

Cancer

Hedgehog Signalling

Hedgehog Signalling

Standard Sonic Hedgehog (Shh) Signaling Modulators| Hedgehog Modulators – Designed by Nature.

NAD+ Metabolome: Linking NAD+ Signalling and Cancer

NAD+ Metabolome: Linking NAD+ Signalling and Cancer

Many and various NAD+-dependent signalling pathways regulate fundamental processes such as transcription, DNA repair, cell cycle progression, apoptosis, proliferation, survival and metabolism, which are linked to cancer development. NAD+-dependent signalling reactions involve the degradation of NAD, therefore permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. Targeting the NAD metabolism, its synthesis and signalling pathways (PARPs, SIRTs, MARTs, CD38) show several effects on cancer cells and are therefore new and promising concepts for cancer treatment.

Stem Cell Fate and Cancer

Stem Cell Fate and Cancer

Periostin: A bridge between cancer stem cells (CSCs) and their metastatic niches| ANGPTL Proteins in Cancer Metastasis & Stem Cells| SignalLing Pathways — Controlling Stem Cell Fate| Leukemia Inhibitory Factor (LIF)| Stem Cell Modulators| Notch Signalling| Sonic Hedgehog Signalling| FGFs & Stem Cells| Human CD Monoclonal Antibodies for Stem Cell Research| SCF, CSF3 & IL-6 — Growth Factors| PEDF & Rock Inhibitors

The TNF Superfamily: Linking Autoimmune Diseases, Inflammation and Cancer

The TNF Superfamily: Linking Autoimmune Diseases, Inflammation and Cancer

Many of the TNFRSF molecules are expressed in cells of the immune system, which implies that they may be central to autoimmune and inflammatory diseases as well as cancer. However, their function is not restricted to immune cells, members of these superfamilies have been linked to an array of pathophysiologies, including cancer, neurologic diseases, cardiovascular diseases, pulmonary diseases, autoimmune diseases and metabolic diseases.

TLR Receptor Agonists as Adjuvants

TLR Receptor Agonists as Adjuvants

The immune system has the greatest potential for the specific destruction of tumors with no toxicity to normal tissue and for long-term memory that can prevent cancer recurrence by immunosurveillance. However, the tumor microenvironment can cause a profound immune suppression that interferes with an effective antitumor response and tumor elimination. Novel immunotherapeutic approaches enhance tumor immunity by targeting immune checkpoints or induce the expansion of T cells by potent adjuvants. Toll-like receptor (TLR) agonists activate both the innate and adaptive immune systems, play an important role in antiviral and antitumor immunity, and are exploited as potent adjuvants to enhance tumor immunity.

 

Cancer Research

Cancer Research - March 2015

Cancer Research - March 2015

Periostin| Multimeric Proteins| Cell Death Antibodies| TRAIL Reagents| Immune Checkpoint Antibodies| Inflammasome Antibodies| Notch Ligands|

 

Cell Biology

Cytoskeleton: Microtubules

Cytoskeleton: Microtubules

anti-alpha Tubulin mAbs| Rab1 and Rab6| Polyglutamylation| Microtubule Modulators

Netrin-1 for Generation of iPS Cells

Netrin-1 for Generation of iPS Cells

Recently, Netrin-1 and its receptors DCC (Deleted in Colorectal Carcinoma)or UNC5b, described for their respective survival/death functions in normal and oncogenic contexts, has been identified in a search for soluble regulators/modulators of somatic cell reprogramming to pluripotency


Cell Culture

Ageladine A

Ageladine A

Ageladine A is a Novel non-toxic, cell permeable, pH-dependent Fluorescent Dye for Live Imaging

 

ELISA

ELISA Kits

ELISA Kits

Metabolic Syndrome Biomarkers|Inflammatory Diseases Biomarkers| Cancer & Autoimmune Diseases Biomarkers|

 

Immunology

Advanced Immune-Regulation Reagents

Advanced Immune-Regulation Reagents

Highlights Include: Highly Active hIDO1; Immune Checkpoint Proteins; Interleukin-33 & Innate Lymphocyte 2 [ILC2]; Highly Active IL-1 Superfamily Proteins; Unique BAFF & APRIL Reagents for Autoimmune Research and more.

Inflammasome Signalling: From Innate to Adaptive Immunity

Inflammasome Signalling: From Innate to Adaptive Immunity

Caspase-1 Detection|Standard Antibodies| Signalling Chart| Priming| Microtubule Assembly| Inhibitors/Activators| Flagellin

Innate Immunity: Focus Toll-like Receptor (TLR) Agonists

Innate Immunity: Focus Toll-like Receptor (TLR) Agonists

The innate immune system plays an essential role in the host’s first line of defense against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).

Key Inflammasome Research Tools

Key Inflammasome Research Tools

NLRP3 Antibody| Detect Activated p10 & p20 Caspase-1| Small Molecule NLRP3 Inflammasome Activators & Inhibitors|

TLR4 Agonist Arrays

TLR4 Agonist Arrays

Facilitate the determination of the optimal cell density, time point of analysis and multiplexing of readouts (e.g. cytokine(s) ELISA) of TLR4 specific cellular activation in a highly reproducible and safe procedure.

 

Metabolism

Myokines: Muscle, Exercise and Obesity

Myokines: Muscle, Exercise and Obesity

Myokine Proteins and ELISA Kits| Irisin| ''Browning'' Agents| FGF-21| AMPK Products

Obesity and Diabetes Research

Obesity and Diabetes Research

Focus: White, Brown & Beige/Brite Adipose Tissue


Neuroscience

Neuroscience Research

Neuroscience Research

Neuroinflammation and Inflammasomes | Notch signaling and CNS | Progranulin | Adiponectin | Neurochemicals/Gangliosides | Polyglutamylation

Neuroscience Research Focus: Neuroinflammation & Neuronal Diseases

Neuroscience Research Focus: Neuroinflammation & Neuronal Diseases

Microtubules and Neurodegeneration. Neurodegeneration refers to the progressive loss of structure and/or function of neurons often beginning at the synaptic distal ends of axons. Neurodegenerative diseases exhibit a broad range of clinical symptoms, which share several common pathological features


Proteins

Betatrophin - Controlling β Cell Replication and β Cell Mass

Betatrophin - Controlling β Cell Replication and β Cell Mass

Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a new secreted protein of 198 aa that promotes β cell proliferation and improves glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation.

DYRK Inhibitors

DYRK Inhibitors

DYRK (dual-specificity tyrosine-regulated kinase) family members constitute an evolutionarily conserved family of protein kinases that have been identified in different organisms such as yeast, Drosophila and human.

TNF Ligands Multimeric Proteins: Higher Activity, Lower Endotoxin

TNF Ligands Multimeric Proteins: Higher Activity, Lower Endotoxin

Adipogen Multimeric Proteins are highly active constructs in which two trimeric TNFSF ligands are linked via the oligomeric collagen domain of ACRP30 [ACRP30headless] an therefore mimic the membrane-bound forms of the protein.

 

Small Molecules

Commodity Small Molecules: For the Advancement of Your Research!

Commodity Small Molecules: For the Advancement of Your Research!

AdipoGen Life Sciences offers a comprehensive panel of Standard & Commodity Biochemicals. This flyer gives an overview on a panel of selected small molecules.

Small Molecules Highlights

Small Molecules Highlights

Synthetic Small Molecules| Unique Natural Products| Rare Antibiotics


Ubiquitin

The Ubiquitin Proteasome System

The Ubiquitin Proteasome System

Proteasome Inhibitors| Proteasome Modulators | Fluorescent Probes for Proteasome Activity Measurement | Proteasome Complex Reagents

 

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