Cancer Research Modulators| Antiviral and Anti-inflammatory compounds| Neuroscience Research Reagents
Unique Natural Products & Rare Antibiotics
From Bacterial, Fungal, Marine & Plant Sources
Unique Natural Products & Rare Antibiotics
Discovered by the Nobel Prize Awarded Kitasato Institute for Life Sciences.
Functional Antibodies: Blocking, Neutralizing, Activation & Depletion
Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™))are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Functional grade antibodies are available free of preservatives and tested for low endotoxin content and may be used for activation, neutralizing or blocking studies, both in vitro or in vivo.
Trail & Trail Receptors: Effectors of Apoptotic Signaling
TRAIL Ligand for in vivo Research| TRAIL-R1 specific Ligand| TRAIL Receptors Antibodies for IHC
Modulators of Autophagy Signalling
Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins through a lysosome-dependent degradation pathway.
Small Molecules, Rare Antibiotics & Unique Natural Products
AdipoChem™ is the Biochemicals business division of Adipogen International which was started by former ALEXIS Corporation scientists, manufacturing small molecules, rare antibiotics and natural products.
Standard Sonic Hedgehog (Shh) Signaling Modulators| Hedgehog Modulators – Designed by Nature.
NAD+ Metabolome: Linking NAD+ Signalling and Cancer
Many and various NAD+-dependent signalling pathways regulate fundamental processes such as transcription, DNA repair, cell cycle progression, apoptosis, proliferation, survival and metabolism, which are linked to cancer development. NAD+-dependent signalling reactions involve the degradation of NAD, therefore permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. Targeting the NAD metabolism, its synthesis and signalling pathways (PARPs, SIRTs, MARTs, CD38) show several effects on cancer cells and are therefore new and promising concepts for cancer treatment.
Stem Cell Fate and Cancer
Periostin: A bridge between cancer stem cells (CSCs) and their metastatic niches| ANGPTL Proteins in Cancer Metastasis & Stem Cells| SignalLing Pathways — Controlling Stem Cell Fate| Leukemia Inhibitory Factor (LIF)| Stem Cell Modulators| Notch Signalling| Sonic Hedgehog Signalling| FGFs & Stem Cells| Human CD Monoclonal Antibodies for Stem Cell Research| SCF, CSF3 & IL-6 — Growth Factors| PEDF & Rock Inhibitors
The TNF Superfamily: Linking Autoimmune Diseases, Inflammation and Cancer
Many of the TNFRSF molecules are expressed in cells of the immune system, which implies that they may be central to autoimmune and inflammatory diseases as well as cancer. However, their function is not restricted to immune cells, members of these superfamilies have been linked to an array of pathophysiologies, including cancer, neurologic diseases, cardiovascular diseases, pulmonary diseases, autoimmune diseases and metabolic diseases.
TLR Receptor Agonists as Adjuvants
The immune system has the greatest potential for the specific destruction of tumors with no toxicity to normal tissue and for long-term memory that can prevent cancer recurrence by immunosurveillance. However, the tumor microenvironment can cause a profound immune suppression that interferes with an effective antitumor response and tumor elimination. Novel immunotherapeutic approaches enhance tumor immunity by targeting immune checkpoints or induce the expansion of T cells by potent adjuvants. Toll-like receptor (TLR) agonists activate both the innate and adaptive immune systems, play an important role in antiviral and antitumor immunity, and are exploited as potent adjuvants to enhance tumor immunity.
Cancer Research - March 2015
Periostin| Multimeric Proteins| Cell Death Antibodies| TRAIL Reagents| Immune Checkpoint Antibodies| Inflammasome Antibodies| Notch Ligands|
anti-alpha Tubulin mAbs| Rab1 and Rab6| Polyglutamylation| Microtubule Modulators
Netrin-1 for Generation of iPS Cells
Recently, Netrin-1 and its receptors DCC (Deleted in Colorectal Carcinoma)or UNC5b, described for their respective survival/death functions in normal and oncogenic contexts, has been identified in a search for soluble regulators/modulators of somatic cell reprogramming to pluripotency
Ageladine A is a Novel non-toxic, cell permeable, pH-dependent Fluorescent Dye for Live Imaging
Metabolic Syndrome Biomarkers|Inflammatory Diseases Biomarkers| Cancer & Autoimmune Diseases Biomarkers|
Advanced Immune-Regulation Reagents
Highlights Include: CD112R – NEW & UNIQUE Immune Checkpoint Receptor; CD28/B7 Pathway – Importance in PD-1 Therapy; New Role of IL-33 – Expansion of T Regulatory Cells (Treg); Highly Active IL-36 Family Proteins and more
Inflammasome Signalling: From Innate to Adaptive Immunity
Caspase-1 Detection|Standard Antibodies| Signalling Chart| Priming| Microtubule Assembly| Inhibitors/Activators| Flagellin
Innate Immunity: Focus Toll-like Receptor (TLR) Agonists
The innate immune system plays an essential role in the host’s first line of defense against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).
Key Inflammasome Research Tools
NLRP3 Antibody| Detect Activated p10 & p20 Caspase-1| Small Molecule NLRP3 Inflammasome Activators & Inhibitors|
TLR4 Agonist Arrays
Facilitate the determination of the optimal cell density, time point of analysis and multiplexing of readouts (e.g. cytokine(s) ELISA) of TLR4 specific cellular activation in a highly reproducible and safe procedure.
Myokines: Muscle, Exercise and Obesity
Myokine Proteins and ELISA Kits| Irisin| ''Browning'' Agents| FGF-21| AMPK Products
Obesity and Diabetes Research
Focus: White, Brown & Beige/Brite Adipose Tissue
Neuroinflammation and Inflammasomes | Notch signaling and CNS | Progranulin | Adiponectin | Neurochemicals/Gangliosides | Polyglutamylation
Neuroscience Research Focus: Neuroinflammation & Neuronal Diseases
Microtubules and Neurodegeneration. Neurodegeneration refers to the progressive loss of structure and/or function of neurons often beginning at the synaptic distal ends of axons. Neurodegenerative diseases exhibit a broad range of clinical symptoms, which share several common pathological features
Betatrophin - Controlling β Cell Replication and β Cell Mass
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a new secreted protein of 198 aa that promotes β cell proliferation and improves glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation.
DYRK (dual-specificity tyrosine-regulated kinase) family members constitute an evolutionarily conserved family of protein kinases that have been identified in different organisms such as yeast, Drosophila and human.
TNF Ligands Multimeric Proteins: Higher Activity, Lower Endotoxin
Adipogen Multimeric Proteins are highly active constructs in which two trimeric TNFSF ligands are linked via the oligomeric collagen domain of ACRP30 [ACRP30headless] an therefore mimic the membrane-bound forms of the protein.
Commodity Small Molecules: For the Advancement of Your Research!
AdipoGen Life Sciences offers a comprehensive panel of Standard & Commodity Biochemicals. This flyer gives an overview on a panel of selected small molecules.
Small Molecules Highlights
Synthetic Small Molecules| Unique Natural Products| Rare Antibiotics
The Ubiquitin Proteasome System
Proteasome Inhibitors| Proteasome Modulators | Fluorescent Probes for Proteasome Activity Measurement | Proteasome Complex Reagents