40% off Cryoplatable Primary Human Hepatocytes

40% off Cryoplatable Primary Human Hepatocytes

If your work involves drug development in vitro studies such as hepatotoxicity, drug transport, hepatitis virus infection, hepatic drug metabolism or hepatobiliary excretion, then this offer could be of interest.

From now and until the end of the year, get 40% off on up to four vials of cryoplatable primary human hepatocytes from iXCells Biotechnologies

Offer details

40% discount on IXCells’ Cryoplatable Primary Human Hepatocytes.

The discount is valid on the first two vials of each lot, to a total of 4 vials.

Offer valid until 31st December 2023 only.

Make sure to use code IXC50HEPA when contacting us to redeem this offer!

About iXCells’s Human Hepatocytes

The liver is a vital organ in mammals, and hepatocytes, the major cell type in the liver, play critical roles in protein synthesis, detoxification of various metabolites, transformation of carbohydrates, and the production of biochemical necessary for digestion. 

iXCells Biotechnologies provides high-quality human primary hepatocytes isolated from whole liver of human organ donors and cryopreserved on the day of isolation with ≥5 million cells in each vial.

These cryoplateable primary human hepatocytes (CPHH) reach and maintain a confluent monolayer (>85% confluency) for at least 7 days, express general hepatocyte marker albumin, and show accumulation of lipid droplets.

Each lot of CPHH is QC tested & validated for key Cytochromes P450 (CYPs) enzyme activity induction.

They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. CPHH cannot be subcultured or passaged.

Plateable Human Hepatocytes 6 well culture dish
Figure 1. Phase contrast images of CPHH. CPHH were plated in a 6-well culture dish (2 million cells/well) and cultured for 7 days. CPHH reached and maintained monolayer with >90% confluency. Hepatocytes exhibited hexagonal shape with single or double nuclei and characteristic “chicken wire” like bile canaliculus formation between hepatocytes.
Immunostaining and Oil Red O staining of cultured CPHH at D5
Figure 2. Immunostaining and Oil Red O staining of cultured CPHH at D5. CPHH were plated in a 12-well culture dish (750,000 cells/well) and cultured for 5 days.(A) Albumin recognized by anti-human albumin antibody (green), and cytoskeleton marker F actin was revealed by Alexa Fluor 555 Phalloidin (red), with cell nuclei counterstained by DAPI (blue). (B) Lipid droplet staining using Oil red O in CPHH.
P450 CYP activities induced by Omeprazole or Rifampin
Figure 3. P450 CYP activities induced by Omeprazole or Rifampin. CPHH were plated in a 12-well culture dish (750,000 cells/well) and incubated with appropriate inducers for 48 hours. Supernatant from induced and uninduced cells were analyzed using P450-Glo™ Assay (Promega, Cat. No. V8421; V8911). The fold changes of the drug induced P450 CYP enzyme activity over the basal level were calculated.

Don’t miss out on this offer to enhance your research and save on your essential supplies.
Claim your discounted hepatocytes now!

Discover XCell’s Range of Liver Products

Explore a diverse range of liver cells, including Human Hepatic Stellate Cells (Adult), Stellate Cells Growth Medium, Human Hepatic Stellate Cells NASH, Human Hepatic Sinusoidal Endothelial Cells (Adult), and more. Reach out to us to learn more!

iXCells Biotechnologies‘ liver cells have been featured in research publications on liver fibrosis, nonalcoholic steatohepatitis (NASH), ADME/TOX, and liver organ-on a chip models, attesting to their high quality and performance.

Caltag Medsystems is the distributor of IXCells Biotechnolgies in the UK and Ireland.

40% off Cryoplatable Primary Human Hepatocytes
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