{"id":10373,"date":"2024-06-07T15:58:22","date_gmt":"2024-06-07T15:58:22","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=10373"},"modified":"2025-07-25T16:15:15","modified_gmt":"2025-07-25T16:15:15","slug":"amp-activated-protein-kinase-ampk-role-in-cancer-and-metabolic-diseases","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/amp-activated-protein-kinase-ampk-role-in-cancer-and-metabolic-diseases\/","title":{"rendered":"AMP-activated protein kinase (AMPK) Role in Cancer and Metabolic Diseases"},"content":{"rendered":"\n<p>The primary\u00a0role of <strong>AMP-activated protein kinase (AMPK)<\/strong> is as a cellular energy sensor. Activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways while inhibiting energy-consuming processes. In non-canonical pathways, AMPK senses the availability of glucose, glycogen or fatty acids and as a result, it senses damage to lysosomes and nuclear DNA. Overall,\u00a0the role of AMPK can\u00a0be observed in cancer, obesity, diabetes, and nonalcoholic steatohepatitis (NASH) thus making it a focus area for therapeutic considerations.<\/p>\n\n\n\n<p>MBL International\u2019s <strong><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=1616894&amp;group_1=All&amp;group_2=All&amp;supplier=10&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=ampk\">AMPK kinase assay kit<\/a> (CY-1182) <\/strong>is highly cited. The AMPK kinase assay kit can be used to measure the activity of AMPK for 96 assays. Applications of the kit include screening activators or inhibitors of AMPK, evaluating the effects of pharmacological agents on AMPK in vitro or monitoring the effects of purification of AMPK.<\/p>\n\n\n\n<p>Additionally,<strong> MBLI\u00a0 AMPK antibodies<\/strong> are designed to detect specific Knockout validated and phosphorylated AMPK targets in the AMPK pathway.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-259.png\"><img loading=\"lazy\" decoding=\"async\" width=\"377\" height=\"240\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-259.png\" alt=\"\" class=\"wp-image-10374\" style=\"width:454px;height:auto\" srcset=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-259.png 377w, https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-259-300x191.png 300w\" sizes=\"auto, (max-width: 377px) 100vw, 377px\" \/><\/a><\/figure>\n\n\n\n<div class=\"wp-block-buttons clear is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/docs.php?Type=Documents&amp;Category=&amp;Manufacturer_ID=0&amp;sortorder=ID&amp;sortdir=DESC&amp;searchterm=ampk&amp;viewdocuments=\" style=\"color:#fbc100;background-color:#21318f\"><strong>Download the AMPK Signalling Pathway Poster<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<p class=\"clear\"> <\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background\" style=\"background-color:#21318f;color:#21318f\"\/>\n\n\n\n<p>Information provided by\u00a0<a href=\"https:\/\/www.caltagmedsystems.co.uk\/mbl\/\">MBL<\/a>.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.caltagmedsystems.co.uk\/\">Caltag Medsystems&nbsp;<\/a>is the distributor of&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/mbl\/\">MBL&nbsp;<\/a>products in the UK and Ireland. If you have any questions about these products, please&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">contact us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MBL International\u2019s AMPK kinase assay kit can be used to measure the activity of AMPK, a cellular energy sensor.<\/p>\n","protected":false},"author":13,"featured_media":12368,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[718,1],"tags":[898,67],"class_list":["post-10373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assay-kit","category-general-information","tag-ampk","tag-mbl-international"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/10373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=10373"}],"version-history":[{"count":3,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/10373\/revisions"}],"predecessor-version":[{"id":10378,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/10373\/revisions\/10378"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/12368"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=10373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=10373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=10373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}