{"id":1105,"date":"2016-05-09T09:29:20","date_gmt":"2016-05-09T09:29:20","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=1105"},"modified":"2019-07-24T13:11:54","modified_gmt":"2019-07-24T13:11:54","slug":"give-your-research-100-with-a-s100-antibody","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/give-your-research-100-with-a-s100-antibody\/","title":{"rendered":"Give Your Research 100% With a S100 Antibody"},"content":{"rendered":"<p>S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.<\/p>\n<ol>\n<li>The S100 protein family consists of 21 proteins that exhibit structural similarity. However, many of the proteins differ in their function<sup>(1)<\/sup>.<\/li>\n<li>Calcium binding activates S100 proteins. S100 proteins undergo a conformation change, thereby allowing interaction with other proteins<sup>(2)<\/sup>.<\/li>\n<li>S100 proteins regulate levels of nucleic acids and a variety of proteins such as enzymes, receptors and transcription factors<sup>(3)<\/sup>.<\/li>\n<li>Some S100 proteins interact with intracellular targets. An example is S100A6, which can bind p53 in the cytosol to regulate apoptosis<sup>(3)<\/sup>.<\/li>\n<li>Some S100 proteins interact with extracellular targets. These interactions include binding to extracellular receptors or binding extracellular circulating proteins<sup>(3)<\/sup>.<\/li>\n<li>S100 proteins are involved in many important cellular processes such as apoptosis, inflammation, energy metabolism and proliferation<sup>(3)<\/sup>.<\/li>\n<li>S100 proteins have been implicated in a variety of cancers<sup>(1)(2)<\/sup>. The specific ways S100 proteins are involved in cancer will be discussed in a future post.<\/li>\n<\/ol>\n<p>MBL International offers a variety of S100 products to meet your research needs including S100 antibodies and S100 ELISA Kits. With a S100 antibody and a S100 ELISA kit, it&#8217;ll be easier for you to further explore these fascinating proteins.<\/p>\n<ul>\n<li><a href=\"http:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=713870\" target=\"_blank\" rel=\"noopener noreferrer\">Anti-S100A6 Polyclonal Antibody Application: WB<\/a><\/li>\n<li><a href=\"http:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=780060\" target=\"_blank\" rel=\"noopener noreferrer\">S100A12\/EN-RAGE ELISA Kit<\/a><\/li>\n<li><a href=\"http:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=376843\">CircuLex S100A9\/MRP14 ELISA Kit<\/a><\/li>\n<li><a href=\"http:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=376842\" target=\"_blank\" rel=\"noopener noreferrer\">CircuLex S100A8\/MRP8 ELISA Kit<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/mbl-international-posters\/\" target=\"_blank\" rel=\"attachment noopener wp-att-1424 noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1424\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/Circadian_Rhythm_CTA.png\" alt=\"circadian rhythm poster request\" width=\"669\" height=\"476\" srcset=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/Circadian_Rhythm_CTA.png 669w, https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/Circadian_Rhythm_CTA-300x213.png 300w\" sizes=\"auto, (max-width: 669px) 100vw, 669px\" \/><\/a><\/p>\n<ol>\n<li>Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer. Nat Rev Cancer. 2015;15(2):96-109.<\/li>\n<li>Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4(2):89-115.<\/li>\n<li>Donato R, Cannon BR, Sorci G, et al. Functions of S100 proteins. Curr Mol Med. 2013;13(1):24-57.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins. The S100 protein family consists of<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[115,10,29],"tags":[116,7,50,67,114],"class_list":["post-1105","post","type-post","status-publish","format-standard","hentry","category-apoptosis","category-cancer","category-immunology","tag-apoptosis","tag-cancer","tag-immunology","tag-mbl-international","tag-s100"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/1105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=1105"}],"version-history":[{"count":6,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/1105\/revisions"}],"predecessor-version":[{"id":4991,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/1105\/revisions\/4991"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=1105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=1105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=1105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}