{"id":11491,"date":"2025-03-17T11:08:46","date_gmt":"2025-03-17T11:08:46","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=11491"},"modified":"2025-03-18T15:54:13","modified_gmt":"2025-03-18T15:54:13","slug":"immune-checkpoint-proteins","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/immune-checkpoint-proteins\/","title":{"rendered":"KACTUS: Immune Checkpoint Proteins"},"content":{"rendered":"\n

Background<\/h2>\n\n\n\n

Immune checkpoints are a series of molecules expressed on immune cells that regulate the degree of immune activation, preventing excessive activation of the immune system. Dysfunction in the expression or function of immune checkpoints is a significant cause of many diseases. Tumour cells often keep immune checkpoints activated, preventing antigens from being presented to T cells, thereby impairing the normal immune function of T cells and enabling immune evasion. Common immune checkpoints include CTLA-4 (cytotoxic T lymphocyte-associated antigen-4) and PD-1 (programmed death receptor-1), which are receptors on the surface of T lymphocytes.<\/p>\n\n\n\n

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Mechanism of action of immune checkpoint inhibitors (Giusy Elia, et al, 2020)<\/em><\/figcaption><\/figure>\n\n\n\n

Comprehensive Catalog of Immune Checkpoint Proteins<\/h2>\n\n\n\n

PD-1, PD-L1, CTLA-4, TIGIT, CD40 & more<\/h3>\n\n\n\n

Currently, immune checkpoints remain a hot topic in clinical research, with new targets and drugs emerging continuously. Based on KACTUS’ SAMS\u2122 protein engineering and production platform<\/a>, they have developed a series of immune checkpoint proteins with various tags, covering targets such as PD-1<\/a>, PD-L1<\/a>, CTLA-4<\/a>, TIM-3<\/a>, OX40<\/a>, TIGIT<\/a>, 4-1BB<\/a>, and CD40<\/a>. These proteins have undergone rigorous quality control and are suitable for antibody functional validation, cell function validation, pharmacokinetic analysis, and other disease-related research.<\/p>\n\n\n\n

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Product Features<\/h3>\n\n\n\n

Product Applications<\/h3>\n<\/div>\n\n\n\n
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