Toll-like receptor 1 (TLR1) recognises pathogen-associated molecular patterns (PAMPS) with a specificity for Gram-positive bacteria. TLR1 recognises peptidoglycan and triacyl lipoproteins in concert with TLR2.<\/p>\n
Pam3<\/sub>CSK4<\/sub> is a selective agonist to the TLR1\/TLR2 heterodimer complex. It is a cell permeable and water soluble synthetic tripalmitoylated lipopeptide that activates the acylated amino terminus of bacterial lipoproteins. Pam3<\/sub>CSK4<\/sub> activates monocytes and macrophages, is a potent and effective immune adjuvant, and is also a potent activator of the pro-inflammatory transcription factor NF-\u03baB.<\/p>\n Product Information <\/strong><\/span><\/p>\n Pam3<\/sub>Cys-Ser-(Lys)4<\/sub>. 3HCl (2mg)<\/a><\/p>\n Caltag Medsystems <\/span><\/a>is the distributor of Adipogen Life Sciences<\/a> products in the UK and Ireland. If you have any questions about these products, please contact<\/span><\/a> us<\/span><\/a>.<\/p>\n To view the full list of references related to Pam3<\/sub>CSK4<\/sub>, please click here.<\/a><\/p>\n References<\/span><\/strong><\/p>\n Buwitt-Beckmann et al<\/em> (2005). TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides. The Journal of Biological Chemistry<\/em> 281<\/strong> (14): 9049 \u20139057<\/a><\/p>\n Buwitt-Beckmann et al<\/em> (2005). Lipopeptide structure determines TLR2 dependent cell activation level. The FEBS Journal<\/em> 274<\/strong> (24): 6354-6364<\/a><\/p>\n Mu\u00e8ller et al<\/em> (2000). Immunostimulation by the synthetic lipopeptide P3<\/sub>CSK4<\/sub>: TLR4-independent activation of the ERK1\/2 signal transduction pathway in macrophages. Immunology<\/em> 103<\/strong>: 49-60<\/a><\/p>\n