Toll-like receptor 5 (TLR5) recognises flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-\u03b1, through signalling via the adapter proteins MyD88, TIRAP and TRIF. Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. It activates the innate immune system not only through the TLR5, but through the intracellular NAIP5\/NLRC4 (IPAF) inflammasome protein as well.<\/p>\n
AdipoGen\u00a0Life Sciences<\/span><\/a> offer different types of low endotoxin and high purity flagellins, including pathways specific mutants.\u00a0The Flagellin (NLRC4 Mutant) (rec.) is only detected by TLR5 not by NLRC4, whereas the Flagellin (TLR5 Mutant) (rec.) is only detected by NLRC4.<\/p>\n Product Information<\/strong><\/span><\/p>\n Flagellin (100\u00b5g)<\/a> References<\/span><\/strong><\/p>\n Nempont et al<\/em> (2008). Deletion of flagellin’s hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity. Journal of Immunology<\/em>: 181<\/strong>: 2036-2043<\/a><\/p>\n Caltag Medsystems <\/span><\/a>is the distributor of Adipogen Life Sciences<\/a> products in the UK and Ireland. If you have any questions about these products, please contact<\/span><\/a> us<\/span><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":" Toll-like receptor 5 (TLR5) recognises flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-\u03b1, through signalling via the adapter proteins MyD88, TIRAP and TRIF. Flagellin is the subunit protein<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-165","post","type-post","status-publish","format-standard","hentry","category-general-information"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=165"}],"version-history":[{"count":7,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/165\/revisions"}],"predecessor-version":[{"id":7537,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/165\/revisions\/7537"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nFlagellin – high purity (10\u00b5g)<\/a>
\nFlagellin (NLRC4 Mutant) (rec.) (10\u00b5g)<\/a>
\nFlagellin (TLR5 Mutant) (rec.)\u00a0(10\u00b5g)<\/a><\/p>\n