{"id":2770,"date":"2017-09-05T10:15:15","date_gmt":"2017-09-05T10:15:15","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=2770"},"modified":"2022-02-25T11:56:34","modified_gmt":"2022-02-25T11:56:34","slug":"novel-molecular-insights-into-classical-and-alternative-activation-states-of-microglia","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/novel-molecular-insights-into-classical-and-alternative-activation-states-of-microglia\/","title":{"rendered":"Novel Molecular Insights into Classical and Alternative Activation States of Microglia"},"content":{"rendered":"

ScienCell\u2019s\u00a0Mouse Microglia<\/a>\u00a0Used\u00a0in Recent Microglial Activation Research Published in Molecular & Cellular Proteomics Journal<\/h3>\n

Microglia\u00a0are a type of macrophage-like glial cell\u00a0in the central nervous system (CNS) and they function as the\u00a0brain\u2019s primary immune defenders.\u00a0Upon activation, microglia may act as\u00a0scavengers, remove tissue debris, and clear damaged cells during CNS\u00a0development or injury. There is also\u00a0evidence that microglia are involved in a variety of physiological and pathological processes in the brain through interactions with neurons, other glial cells, and the production of biologically active substances such as growth factors and cytokines.<\/p>\n

Researchers at\u00a0the University of South Florida (Department of Cell Biology, Microbiology, and Molecular Biology) used ScienCell\u2019s mouse microglia in their research on the\u00a0molecular mechanisms behind classical and alternative microglial activation<\/a>.\u00a0Through this study, they\u00a0found a group of proteins differentially expressed in the classical M1, pro-inflammatory state and M2 (M2a, M2b, M2c) alternative activation. The data revealed new insights into the similarities and differences between the various states. Additionally, the proteomic data revealed a novel activation marker DAB2, which was\u00a0notably different between the various states.<\/p>\n

Read full paper:\u00a0http:\/\/www.mcponline.org\/content\/14\/12\/3173.full.pdf<\/a><\/p>\n

\"Novel<\/a><\/p>\n

 <\/p>\n

Originally Posted on 29th of September 2016: \u00a0https:\/\/sciencellonline.com\/blog\/novel-molecular-insights-into-classical-and-alternative-activation-states-of-microglia\/<\/p>\n

ScienCell is distributed by Caltag Medsystems, to see more click here<\/a>.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

ScienCell\u2019s\u00a0Mouse Microglia\u00a0Used\u00a0in Recent Microglial Activation Research Published in Molecular & Cellular Proteomics Journal Microglia\u00a0are a type of macrophage-like glial cell\u00a0in the central nervous system (CNS) and they function as the\u00a0brain\u2019s primary immune defenders.\u00a0Upon activation, microglia may act as\u00a0scavengers, remove tissue<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[344,345,346,347,348,349,350,351,352,353,282,321],"class_list":["post-2770","post","type-post","status-publish","format-standard","hentry","category-general-information","tag-dab2","tag-glial-cell","tag-macrophage","tag-microglia","tag-microglia-activation","tag-microglial-activation","tag-molecular-cellular-proteomics-journal","tag-molecular-mechanisms-behind-classical-and-alternative-microglial-activation","tag-mouse-microglia","tag-novel-molecular-insights-into-classical-and-alternative-activation-states-of-microglia-as-revealed-by-stable-isotope-labeling-by-amino-acids-in-cell-culture-silac-based-proteomics","tag-sciencell","tag-sciencell-blog"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/2770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=2770"}],"version-history":[{"count":3,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/2770\/revisions"}],"predecessor-version":[{"id":2775,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/2770\/revisions\/2775"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=2770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=2770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=2770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}