{"id":3225,"date":"2018-03-07T13:54:42","date_gmt":"2018-03-07T13:54:42","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=3225"},"modified":"2022-06-21T15:24:28","modified_gmt":"2022-06-21T15:24:28","slug":"pd-1-immune-checkpoint","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/pd-1-immune-checkpoint\/","title":{"rendered":"PD-1 Immune Checkpoint"},"content":{"rendered":"<p><a href=\"https:\/\/www.caltagmedsystems.co.uk\/prosci\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-1145\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/ProSci-Logo160.jpg\" alt=\"Prosci logo, prosci incorporated\" width=\"160\" height=\"72\"><\/a>The PD-1 protein is a negative co-stimulatory receptor that can bind two different but related ligands, PD-L1 and PD-L2. Upon binding, signals generated by PD-1 inhibit the activation of the immune response in the absence of &#8220;danger signals.&#8221;<\/p>\n<p>ProSci Inc. offers an extensive range of antibodies and supporting tools to research PD-1. Read more about their range below, or click a link to jump to a specific section:<\/p>\n<ul>\n<li><a href=\"#3\">Risk-Free&#x2122; Single Domain Monoclonal PD-1 Products<\/a><\/li>\n<li><a href=\"#2\">Risk-Free&#x2122; Mouse Monoclonal PD-1 Products<\/a><\/li>\n<li><a href=\"#1\">PD-1 Matched Antibody Pairs<\/a><\/li>\n<li><a href=\"#4\">Additional PD-1 Antibodies<\/a><\/li>\n<li><a href=\"#5\">Related PD-1 Products<\/a><\/li>\n<li><a href=\"#6\">Further Information on PD-1<\/a><\/li>\n<\/ul>\n<hr>\n<h2>Risk-Free&#x2122; Single Domain Monoclonal PD-1 Products<\/h2>\n<p style=\"text-align: center;\"><a class=\"button_large\" href=\"https:\/\/www.caltagmedsystems.co.uk\/docs\/SABPA%20Risk-FreeTM%20Immune%20Checkpoints%20mAbs%20&amp;%20sdAbs%20Products%20[2-sided]%20.pdf\">Download Immune Checkpoints Flyer<\/a><\/p>\n<p><a href=\"https:\/\/www.prosci-inc.com\/custom-antibody-services\/single-domain-antibodies\/applications\/\">Llama single domain antibodies<\/a> (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: PD-1 antibody should be stored in working aliquots at -20 \u00b0C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. PD-1 antibodies should not be exposed to prolonged high temperatures.<\/p>\n<h3>Risk-Free&#x2122; Single Domain Monoclonal PD-1 Set<\/h3>\n\n<table id=\"tablepress-46\" class=\"tablepress tablepress-id-46\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Product Set<\/th><th class=\"column-2\">Size<\/th><th class=\"column-3\">Contents<\/th><th class=\"column-4\">Description<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=969561\" rel=\"noopener\" target=\"_blank\">Single Domain Set<br>(SD8600)<\/a><\/td><td class=\"column-2\">20ug\/ clone<\/td><td class=\"column-3\">PSI-SD8643, PSI-SD8645, PSI-SD8647, PSI-SD8649<\/td><td class=\"column-4\">Llama single domain monoclonal PD-1 antibodies were raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-46 from cache -->\n<h3>Risk-Free&#x2122; Single Domain Monoclonal PD-1 Antibodies<\/h3>\n\n<table id=\"tablepress-47\" class=\"tablepress tablepress-id-47\" aria-describedby=\"tablepress-47-description\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Clone<\/th><th class=\"column-3\">ELISA<\/th><th class=\"column-4\">WB<\/th><th class=\"column-5\">ICC<\/th><th class=\"column-6\">IF<\/th><th class=\"column-7\">IHC<\/th><th class=\"column-8\">Flow<\/th><th class=\"column-9\">Functional<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-SD8643\" rel=\"noopener\" target=\"_blank\">PSI-SD8643<\/a><\/td><td class=\"column-2\">F1-2A8<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8643-elisa.gif\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\">-<\/td><td class=\"column-6\">?<\/td><td class=\"column-7\">?<\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8643-flow-2.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-9\">++<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-SD8645\" rel=\"noopener\" target=\"_blank\">PSI-SD8645<\/a><\/td><td class=\"column-2\">F4-2D7<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8645-elisa.gif\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\">-<\/td><td class=\"column-6\">?<\/td><td class=\"column-7\">?<\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8645-flow-2.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-9\">-<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-SD8647\" rel=\"noopener\" target=\"_blank\">PSI-SD8647<\/a><\/td><td class=\"column-2\">F3-4C9<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8647-elisa.gif\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\">-<\/td><td class=\"column-6\">?<\/td><td class=\"column-7\">?<\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8647-flow-2.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-9\">-<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-SD8649\" rel=\"noopener\" target=\"_blank\">PSI-SD8649<\/a><\/td><td class=\"column-2\">F2-5F4<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8643-elisa.gif\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\">-<\/td><td class=\"column-6\">?<\/td><td class=\"column-7\">?<\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/sdabs\/pd1-sd8643-flow-2.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-9\">+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<span id=\"tablepress-47-description\" class=\"tablepress-table-description tablepress-table-description-id-47\">\"?\"=Not yet determined, \"-\"=Negative, \"+\"=Fair, \"++\"=Average, \"+++\"=Good, \"++++\"=Excellent. <br \/>\nClick specific applications to see respective validation image.<\/span>\n<!-- #tablepress-47 from cache -->\n<hr>\n<h2>Risk-Free&#x2122; Mouse Monoclonal PD-1 Products<\/h2>\n<p><a href=\"https:\/\/www.prosci-inc.com\/immune-checkpoints\/risk-free\">ProSci&#8217;s Risk-Free&#x2122; antibodies<\/a> are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free&#x2122; antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free&#x2122; means they are guaranteed to work for their approved applications.<\/p>\n<h3>Risk-Free&#x2122; Mouse Monoclonal PD-1 Set<\/h3>\n<p><a href=\"https:\/\/www.prosci-inc.com\/immune-checkpoints\/risk-free-sets\">ProSci&#8217;s Risk-Free&#x2122; Sets<\/a> consists of several mAbs with different binding features allowing selection of the best clone.<\/p>\n\n<table id=\"tablepress-44\" class=\"tablepress tablepress-id-44\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Product Set<\/th><th class=\"column-2\">Size<\/th><th class=\"column-3\">Contents<\/th><th class=\"column-4\">Description<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=969575\" rel=\"noopener\" target=\"_blank\">Risk-Free PD-1 Set<br> (PSI-RF16000)<\/a><\/td><td class=\"column-2\">20ug\/ clone<\/td><td class=\"column-3\">PSI-RF16001, PSI-RF16002, PSI-RF16003, PSI-RF16004, PSI-RF16005<\/td><td class=\"column-4\">Mouse monoclonal PD-1 antibodies were raised against the extracellular domain of human PD-1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-44 from cache -->\n<h3>Risk-Free&#x2122; Mouse Monoclonal PD-1 Antibodies<\/h3>\n\n<table id=\"tablepress-45\" class=\"tablepress tablepress-id-45\" aria-describedby=\"tablepress-45-description\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Epitope Map<\/th><th class=\"column-3\">ELISA<\/th><th class=\"column-4\">WB<\/th><th class=\"column-5\">ICC<\/th><th class=\"column-6\">IF<\/th><th class=\"column-7\">IHC<\/th><th class=\"column-8\">Flow<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16001\" rel=\"noopener\" target=\"_blank\">PSI-RF16001<\/a><\/td><td class=\"column-2\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/epitope-map-rf16001.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/epitope-map-rf16001.png\" alt=\"\" width=\"150\" height=\"75\" class=\"aligncenter size-full wp-image-3244\" \/><\/a><\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-05-elisa-curve.png\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-3-wb.png\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16001\/pd1-rf16001-icc.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16001\/pd1-rf16001-if.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16001\/pd1-rf16001-ihc.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16002\" rel=\"noopener\" target=\"_blank\">PSI-RF16002<\/a><\/td><td class=\"column-2\">Conformation Specific<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-05-elisa-curve.png\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-3-wb.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16002\/pd1-rf16002-icc.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16002\/pd1-rf16002-if.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16002\/pd1-rf16002-ihc.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16003\" rel=\"noopener\" target=\"_blank\">PSI-RF16003<\/a><\/td><td class=\"column-2\">Conformation Specific<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-05-elisa-curve.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-3-wb.png\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16003\/pd1-rf16003-icc.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16003\/pd1-rf16003-if.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16003\/pd1-rf16003-ihc.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16003\/pd1-rf16003-flow-2.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16004\" rel=\"noopener\" target=\"_blank\">PSI-RF16004<\/a><\/td><td class=\"column-2\">Conformation Specific<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-05-elisa-curve.png\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16004\/pd1-rf16004-icc.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16004\/pd1-rf16004-if.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16004\/pd1-rf16004-ihc.png\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16004\/pd1-rf16004-flow-2.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16005\" rel=\"noopener\" target=\"_blank\">PSI-RF16005<\/a><\/td><td class=\"column-2\">Conformation Specific<\/td><td class=\"column-3\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pd1-rf16001-05-elisa-curve.png\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-4\">-<\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16005\/pd1-rf16005-icc.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16005\/pd1-rf16005-if.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16005\/pd1-rf16005-ihc.png\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-8\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/rf16005\/pd1-rf16005-flow-2.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<span id=\"tablepress-45-description\" class=\"tablepress-table-description tablepress-table-description-id-45\">\"-\"=Negative, \"+\"=Fair, \"++\"=Average, \"+++\"=Good, \"++++\"=Excellent. <br \/>\nClick specific applications to see respective validation image.<\/span>\n<!-- #tablepress-45 from cache -->\n<hr>\n<h2>PD-1 Matched Antibody Pairs<\/h2>\n<p>A sandwich ELISA was performed using the anti-PD-1 mAbs PSI-RF16001, PSI-RF16002, PSI-RF16003, PSI-RF16004, and PSI-RF16005 as the capture antibodies for the PD-1 extracellular domain antigen with HRP-labeled Risk-Free&#x2122; anti-PD-1 mAbs as the detection antibodies.<\/p>\n\n<table id=\"tablepress-43\" class=\"tablepress tablepress-id-43\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Target<\/th><th class=\"column-2\">Matched Pair<\/th><th class=\"column-3\">Capture Antibody<\/th><th class=\"column-4\">Detection Antibody<\/th><th class=\"column-5\">Host<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">PD-1 Human Matched Antibody Pair #1<\/td><td class=\"column-2\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RFP-0001\" rel=\"noopener\" target=\"_blank\">PSI-RFP-0001<\/a><\/td><td class=\"column-3\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16004\" rel=\"noopener\" target=\"_blank\">PSI-RF16004<\/a><\/td><td class=\"column-4\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16003-HRP\" rel=\"noopener\" target=\"_blank\">PSI-RF16003-HRP<\/a><\/td><td class=\"column-5\">Mouse - Mouse<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">PD-1 Human Matched Antibody Pair #2<\/td><td class=\"column-2\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RFP-0002\" rel=\"noopener\" target=\"_blank\">PSI-RFP-0002<\/a><\/td><td class=\"column-3\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16005\" rel=\"noopener\" target=\"_blank\">PSI-RF16005<\/a><\/td><td class=\"column-4\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF16002-HRP\" rel=\"noopener\" target=\"_blank\">PSI-RF16002-HRP<\/a><\/td><td class=\"column-5\">Mouse - Mouse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-43 from cache -->\n<figure id=\"attachment_3235\" aria-describedby=\"caption-attachment-3235\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/pd1-rf16001-5-elisa.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3235\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/pd1-rf16001-5-elisa-300x231.gif\" alt=\"PD-1 Human Matched Antibody Pair capture ELISA Data from prosci\" width=\"300\" height=\"231\"><\/a><figcaption id=\"caption-attachment-3235\" class=\"wp-caption-text\">Capture ELISA Data<\/figcaption><\/figure>\n<hr>\n<h2>Additional PD-1 Antibodies<\/h2>\n<p>Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20\u02daC and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.<\/p>\n<h3>Monoclonal PD-1 Products<\/h3>\n\n<table id=\"tablepress-48\" class=\"tablepress tablepress-id-48\" aria-describedby=\"tablepress-48-description\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Clone<\/th><th class=\"column-3\">ELISA<\/th><th class=\"column-4\">WB<\/th><th class=\"column-5\">ICC<\/th><th class=\"column-6\">IF<\/th><th class=\"column-7\">IHC<\/th><th class=\"column-8\">Flow<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-PM-5177\" rel=\"noopener\" target=\"_blank\">PSI-PM-5177<\/a><\/td><td class=\"column-2\">7A11B1<\/td><td class=\"column-3\">++++<\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5177-wb.jpg\">+<\/a><\/td><td class=\"column-5\">?<\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5177-if.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5177-ihc.gif\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-PM-5179\" rel=\"noopener\" target=\"_blank\">PSI-PM-5179<\/a><\/td><td class=\"column-2\">12A7D7<\/td><td class=\"column-3\">++++<\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5179-wb.jpg\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-5\">?<\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5179-if.gif\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/mabs\/pd1-pm5179-ihc.jpg\" rel=\"noopener\" target=\"_blank\">++<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<span id=\"tablepress-48-description\" class=\"tablepress-table-description tablepress-table-description-id-48\">\"?\"=Not yet determined, \"-\"=Negative, \"+\"=Fair, \"++\"=Average, \"+++\"=Good, \"++++\"=Excellent. <br \/>\nClick specific applications to see respective validation image.<\/span>\n<!-- #tablepress-48 from cache -->\n<h3>Polyclonal PD-1 Products<\/h3>\n\n<table id=\"tablepress-49\" class=\"tablepress tablepress-id-49\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Antigen Range<\/th><th class=\"column-3\">ELISA<\/th><th class=\"column-4\">WB<\/th><th class=\"column-5\">ICC<\/th><th class=\"column-6\">IF<\/th><th class=\"column-7\">IHC<\/th><th class=\"column-8\">Flow<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-4065\" rel=\"noopener\" target=\"_blank\">PSI-4065<\/a><\/td><td class=\"column-2\">210 - 260<\/td><td class=\"column-3\">++++<\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4065-wb.jpg\" rel=\"noopener\" target=\"_blank\">++++<\/a><\/td><td class=\"column-5\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4065-icc.gif\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-6\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4065-if.jpg\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4065-ihc.jpg\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-4067\" rel=\"noopener\" target=\"_blank\">PSI-4067<\/a><\/td><td class=\"column-2\">120 - 170<\/td><td class=\"column-3\">++++<\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4067-wb.jpg\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-5\">?<\/td><td class=\"column-6\">-<\/td><td class=\"column-7\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-4067-ihc.jpg\" rel=\"noopener\" target=\"_blank\">+<\/a><\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-46-148\" rel=\"noopener\" target=\"_blank\">PSI-46-148<\/a><\/td><td class=\"column-2\">220 - 270<\/td><td class=\"column-3\">++++<\/td><td class=\"column-4\"><a href=\"https:\/\/www.prosci-inc.com\/media\/wysiwyg\/immune-checkpoints\/pd1\/pabs\/pd1-46-148-wb.jpg\" rel=\"noopener\" target=\"_blank\">+++<\/a><\/td><td class=\"column-5\">-<\/td><td class=\"column-6\">-<\/td><td class=\"column-7\">-<\/td><td class=\"column-8\">-<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-49 from cache -->\n<hr>\n<h2>Related PD-1 Products<\/h2>\n<h3>Peptides<\/h3>\n\n<table id=\"tablepress-50\" class=\"tablepress tablepress-id-50\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Location<\/th><th class=\"column-3\">Species<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-4065P\" rel=\"noopener\" target=\"_blank\">PSI-4065P<\/a><\/td><td class=\"column-2\">16 amino acids near the carboxy terminus of human PD-1\t<\/td><td class=\"column-3\">Human<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-4067P\" rel=\"noopener\" target=\"_blank\">PSI-4067P<\/a><\/td><td class=\"column-2\">16 amino acids near the center of human PD-1<\/td><td class=\"column-3\">Human<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-46-148P\" rel=\"noopener\" target=\"_blank\">PSI-46-148P<\/a><\/td><td class=\"column-2\">PDCD1 peptide corresponds to 13 amino acids of PDCD1<\/td><td class=\"column-3\">Human<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-50 from cache -->\n<h3>Antigen<\/h3>\n\n<table id=\"tablepress-51\" class=\"tablepress tablepress-id-51\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Product Type<\/th><th class=\"column-3\">Species<\/th><th class=\"column-4\">Tissue\/ Cell<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=970723\" rel=\"noopener\" target=\"_blank\">PSI-RF16000-01<\/a><\/td><td class=\"column-2\">Recombinant Protein\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">HEK293<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=969283\" rel=\"noopener\" target=\"_blank\">PSI-RF16000-02<\/a><\/td><td class=\"column-2\">Risk-Free PD-1 Mapping Peptide Set<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-51 from cache -->\n<h3>Lysates<\/h3>\n\n<table id=\"tablepress-52\" class=\"tablepress tablepress-id-52\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Product Type<\/th><th class=\"column-3\">Species<\/th><th class=\"column-4\">Tissue\/ Cell<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10001-01\" rel=\"noopener\" target=\"_blank\">PSI-RF10001-01<\/a><\/td><td class=\"column-2\">Positive Control (Cell Lysate)\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">THP-1<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10001-03\" rel=\"noopener\" target=\"_blank\">PSI-RF10001-03<\/a><\/td><td class=\"column-2\">Positive Control (Tissue Lysate)\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">Spleen<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10001-04\" rel=\"noopener\" target=\"_blank\">PSI-RF10001-04<\/a><\/td><td class=\"column-2\">Positive Control (Tissue Lysate)\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">Tonsil<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10001-05\" rel=\"noopener\" target=\"_blank\">PSI-RF10001-05<\/a><\/td><td class=\"column-2\">Positive Control (Tissue Lysate)\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">Lymph Node<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10001-02\" rel=\"noopener\" target=\"_blank\">PSI-RF10001-02<\/a><\/td><td class=\"column-2\">Negative Control (Cell Lysate)<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">HEK293<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-52 from cache -->\n<h3>Slides<\/h3>\n\n<table id=\"tablepress-53\" class=\"tablepress tablepress-id-53\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Cat. Number<\/th><th class=\"column-2\">Product Type<\/th><th class=\"column-3\">Species<\/th><th class=\"column-4\">Tissue\/ Cell<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10002-01\" rel=\"noopener\" target=\"_blank\">PSI-RF10002-01<\/a><\/td><td class=\"column-2\">Positive Control (Cells)<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">THP-1<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=PSI-RF10002-03\" rel=\"noopener\" target=\"_blank\">PSI-RF10002-03<\/a><\/td><td class=\"column-2\">Positive Control (Tissue Lysate)\t<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">Spleen<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/search_results.php?searchtype=all&amp;searchwords=RF10002-02\" rel=\"noopener\" target=\"_blank\">RF10002-02<\/a><\/td><td class=\"column-2\">Negative Control (Cells)<\/td><td class=\"column-3\">Human<\/td><td class=\"column-4\">Tonsil<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-53 from cache -->\n<p>Caltag Medsystems offers a multitude of Immune Checkpoint research products from ProSci and other supplier. If you are looking for something else, please <a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">contact us<\/a> and we will be happy to help.<\/p>\n<hr>\n<h2 id=\"6\">Further Information on PD-1<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/a-brief-introduction-to-pd-1-antibodies-and-immunotherapy\/\" target=\"_blank\" rel=\"noopener noreferrer\">Blog: A Brief Introduction to PD-1 Antibodies and Immunotherapy<\/a><\/li>\n<li><a href=\"https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=PDCD1&amp;keywords=pd1\">Genecards: PD-1 Database<\/a><\/li>\n<li><a href=\"https:\/\/www.caltagmedsystems.co.uk\/docs\/SABPA%20Risk-FreeTM%20Immune%20Checkpoints%20mAbs%20&amp;%20sdAbs%20Products%20[2-sided]%20.pdf\">Immune Checkpoints Flyer<\/a><\/li>\n<li><a href=\"https:\/\/www.youtube.com\/watch?v=aobxYfY-8p0\">Video:&nbsp;Cancer Immunotherapy: PD-1 &amp; PD-l1<\/a><\/li>\n<\/ul>\n<p>ProSci products are distributed in the UK by Caltag Medsystems. If you have any questions about the products in this blog, please <a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">contact us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The PD-1 protein is a negative co-stimulatory receptor that can bind two different but related ligands, PD-L1 and PD-L2. Upon binding, signals generated by PD-1 inhibit the activation of the immune response in the absence of &#8220;danger signals.&#8221; ProSci Inc.<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[132,10,29],"tags":[159,146,157,437,77,131],"class_list":["post-3225","post","type-post","status-publish","format-standard","hentry","category-antibodies","category-cancer","category-immunology","tag-immune-checkpoint","tag-monoclonal-antibodies","tag-pd-1","tag-polyclonal-antibodies","tag-prosci","tag-single-domain-antibodies"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3225","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=3225"}],"version-history":[{"count":24,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3225\/revisions"}],"predecessor-version":[{"id":6740,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3225\/revisions\/6740"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=3225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=3225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=3225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}