{"id":3513,"date":"2018-07-09T15:48:21","date_gmt":"2018-07-09T15:48:21","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=3513"},"modified":"2020-03-17T15:24:18","modified_gmt":"2020-03-17T15:24:18","slug":"diaclone-biologically-active-antibodies","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/diaclone-biologically-active-antibodies\/","title":{"rendered":"Diaclone Biologically Active Antibodies"},"content":{"rendered":"

\"\"<\/a>Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies.<\/p>\n

Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies.<\/p>\n

\n

Available Biologically Active Antibodies<\/h2>\n

\"\"<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Specificity (Anti-Human)<\/th>Clone<\/th>Azide Free<\/th>Biological Activity<\/th>\n<\/tr>\n<\/thead>\n
CD10<\/td>B-E3<\/td>854.090.000<\/a><\/td>Cytotoxic In association with rabbit complement on CD10+ cells<\/td>\n<\/tr>\n
CD102 \/ ICAM-2<\/td>B-T1<\/td>852.760.000<\/a><\/td>Inhibits cell adhesion and T-cell activation<\/td>\n<\/tr>\n
CD106 \/ VCAM-1<\/td>B-K9<\/td>852.770.000<\/a><\/td>Inhibits cell attachment to VCAM-1<\/td>\n<\/tr>\n
CD117 \/ c-kit<\/td>B-K15<\/td>854.510.000<\/a><\/td>Inhibits the KIT ligand induced proliferation of TF1 cell line<\/td>\n<\/tr>\n
CD126 \/ IL-6R<\/td>B-R6<\/td>852.030.000<\/a><\/td>Inhibits IL-6 induced proliferation of XG-1 cells<\/td>\n<\/tr>\n
CD130 \/ gp130<\/td>B-S12<\/td>852.110.000<\/a><\/td>Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation<\/td>\n<\/tr>\n
CD130 \/ gp130<\/td>B-P4<\/td>852.090.000<\/a><\/td>Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities<\/td>\n<\/tr>\n
CD130 \/ gp130<\/td>B-P8<\/td>852.080.000<\/a><\/td>Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation<\/td>\n<\/tr>\n
CD130 \/ gp130<\/td>B-K5<\/td>852.070.000<\/a><\/td>Inhibits CNTF activity. Inhibits OSM binding to gp130<\/td>\n<\/tr>\n
CD130 \/ gp130<\/td>B-R3<\/td>852.060.000<\/a><\/td>Inhibits IL-6, IL-11, CNTF, LIF and OSM activities<\/td>\n<\/tr>\n
CD178\/FAS-L<\/td>B-R17<\/td>853.070.000<\/a><\/td>Inhibits soluble CD178 induced apoptosis<\/td>\n<\/tr>\n
CD184<\/td>B-R24<\/td>854.600.000<\/a><\/td>Inhibits HIV-1 infection<\/td>\n<\/tr>\n
CD2 \/ LFA-2<\/td>B-E2<\/td>852.500.000<\/a><\/td>Inhibits mixed lymphocyte culture<\/td>\n<\/tr>\n
CD20<\/td>B-H20<\/td>854.150.000<\/a><\/td>Cytotoxic in association with complement on CD20 cells<\/td>\n<\/tr>\n
CD202b \/ Tie-2 \/ TEK<\/td>B-B48<\/td>854.710.000<\/a><\/td>Inhibits Tek-L \/ Tek binding<\/td>\n<\/tr>\n
CD21<\/td>B-E5<\/td>854.160.000<\/a><\/td>Induces human B-cell proliferation and competes with EBV for CD21 binding<\/td>\n<\/tr>\n
IL-18Ra<\/td>B-E43<\/td>854.900.000<\/a><\/td>Inhibits human IFN\u03b3 secretion induced by IL-18 stimulated cells<\/td>\n<\/tr>\n
IL-18Rb<\/td>B-B46<\/td>854.910.000<\/a><\/td>Inhibits human IFN\u03b3 secretion induced by IL-18 stimulated cells<\/td>\n<\/tr>\n
CD25 \/ IL-2R<\/td>B-F2<\/td>852.010.000<\/a><\/td>Inhibits mixed lymphocyte culture<\/td>\n<\/tr>\n
CD25 \/ IL-2R<\/td>B-B10<\/td>852.000.000<\/a><\/td>Inhibits mixed lymphocyte culture<\/td>\n<\/tr>\n
TRAIL \/ APO2L<\/td>B-T24<\/td>853.090.000<\/a><\/td>Inhibits TRAIL induced apoptosis<\/td>\n<\/tr>\n
TRAIL<\/td>B-S23<\/td>853.080.000<\/a><\/td>Enhances TRAIL induced apoptosis<\/td>\n<\/tr>\n
TRAIL R1 \/ DR4<\/td>B-N36<\/td>854.850.000<\/a><\/td>Neutralizes TRAIL induced apoptosis on HEL cell line<\/td>\n<\/tr>\n
TRAIL R2 \/ DR5<\/td>B-D37<\/td>854.870.000<\/a><\/td>Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line<\/td>\n<\/tr>\n
TRAIL R2 \/ DR5<\/td>B-K29<\/td>854.860.000<\/a><\/td>Neutralizes TRAIL induced apoptosis of U937 cell line<\/td>\n<\/tr>\n
TRAIL R3 \/ DcR1<\/td>B-D44<\/td>854.890.000<\/a><\/td>Inhibits TRAIL binding to TRAIL R3<\/td>\n<\/tr>\n
CD28<\/td>B-T3<\/td>854.220.000<\/a><\/td>Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation.<\/td>\n<\/tr>\n
CD3<\/td>B-B11<\/td>854.010.000<\/a><\/td>Induces T lymphocyte stimulation and proliferation<\/td>\n<\/tr>\n
CD34 Class I<\/td>B-G25<\/td>854.240.000<\/a><\/td>Triggers KG-1a cell aggregation<\/td>\n<\/tr>\n
CD4<\/td>B-A1<\/td>854.030.000<\/a><\/td>Inhibits mixed lymphocyte culture<\/td>\n<\/tr>\n
CD40<\/td>B-B20<\/td>854.280.000<\/a><\/td>Stimulates B-cell proliferation together with IL-4<\/td>\n<\/tr>\n
CD44 \/ PGP-1<\/td>B-F24<\/td>852.600.000<\/a><\/td>Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44<\/td>\n<\/tr>\n
CD54<\/td>B-H17<\/td>852.690.000<\/a><\/td>Inhibits PHA stimulated T-cell proliferation<\/td>\n<\/tr>\n
CD86<\/td>B-T7<\/td>854.450.000<\/a><\/td>Inhibits mixed lymphocyte culture<\/td>\n<\/tr>\n
CD95 \/ FAS<\/td>B-D29<\/td>853.030.000<\/a><\/td>Inhibits FasL induced apoptosis<\/td>\n<\/tr>\n
CD95 \/ FAS<\/td>B-G27<\/td>853.000.000<\/a><\/td>Triggers Fas induced apoptosis<\/td>\n<\/tr>\n
HLA Class I<\/td>W6\/32<\/td>857.220.000<\/a><\/td>Inhibits the interaction between T cells and MHC molecules<\/td>\n<\/tr>\n
IFN gamma<\/td>B-B1<\/td>855.000.005<\/a><\/td>Inhibits IFN\u03b3 induced proliferation<\/td>\n<\/tr>\n
IL-10<\/td>B-S10<\/td>855.100.005<\/a><\/td>Inhibits IL-10 induced proliferation on MC\/9 cell line<\/td>\n<\/tr>\n
IL-12p35+p70<\/td>B-T21<\/td>855.120.005<\/a><\/td>Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes<\/td>\n<\/tr>\n
IL-12p40+p70<\/td>B-P24<\/td>855.130.005<\/a><\/td>Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes<\/td>\n<\/tr>\n
IL-13<\/td>B-B13<\/td>855.140.005<\/a><\/td>Inhibits IL-13 induced proliferation on TF1 cell line<\/td>\n<\/tr>\n
IL-15<\/td>B-E29<\/td>855.220.005<\/a><\/td>Inhibits IL-15 induced proliferation on Kit 225 cell line<\/td>\n<\/tr>\n
IL-17A<\/td>B-B51<\/td>853.910.005<\/a><\/td>Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production)<\/td>\n<\/tr>\n
IL-17F<\/td>B-F60<\/td>855.360.005<\/a><\/td>Neutralises the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production)<\/td>\n<\/tr>\n
IL-1beta<\/td>B-A15<\/td>855.010.005<\/a><\/td>Inhibits IL-1\u03b2 induced proliferation on D10S murine cell line<\/td>\n<\/tr>\n
IL-2<\/td>B-G5<\/td>855.020.005<\/a><\/td>Inhibits IL-2 induced proliferation on CTL-L2 murine cell line<\/td>\n<\/tr>\n
IL-23<\/td>B-Z23<\/td>853.920.005<\/a><\/td>Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI\/6 (measurement of mIL-17 or mIL-22 production)<\/td>\n<\/tr>\n
IL-4<\/td>B-S4<\/td>855.030.005<\/a><\/td>Inhibits IL-4 induced proliferation on TF1 cells<\/td>\n<\/tr>\n
IL-6<\/td>B-E8<\/td>855.050.005<\/a><\/td>Inhibits IL-6 induced proliferation on B9 cells<\/td>\n<\/tr>\n
IL-8<\/td>B-K8<\/td>855.080.005<\/a><\/td>Inhibits IL-8 induced chemotaxis of human neutrophils<\/td>\n<\/tr>\n
NKp46<\/td>B-L46<\/td>855.490.000<\/a><\/td>Measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFN\u03b3 secretion by non-activated NK cells<\/td>\n<\/tr>\n
Neurotensin<\/td>B-N6<\/td>857.040.000<\/a><\/td>Inhibits neurotensin binding to its receptor<\/td>\n<\/tr>\n
TNF alpha<\/td>B-C7<\/td>855.150.005<\/a><\/td>Inhibits TNF\u03b1 induced cytotoxicity on U937 cells<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

Diaclone products are distributed In the UK and Ireland by Caltag Medsystems. If you have any questions about the products in this blog, please contact us<\/a>.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies. Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies. Available Biologically Active Antibodies Diaclone products are<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[132],"tags":[185,446,428],"class_list":["post-3513","post","type-post","status-publish","format-standard","hentry","category-antibodies","tag-antibodies","tag-biologically-active","tag-diaclone"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=3513"}],"version-history":[{"count":19,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3513\/revisions"}],"predecessor-version":[{"id":5791,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/3513\/revisions\/5791"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=3513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=3513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=3513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}