{"id":4639,"date":"2019-05-09T14:25:13","date_gmt":"2019-05-09T14:25:13","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=4639"},"modified":"2019-07-24T15:18:25","modified_gmt":"2019-07-24T15:18:25","slug":"risk-factors-and-treatment-of-depression","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/risk-factors-and-treatment-of-depression\/","title":{"rendered":"Risk Factors and Treatment of Depression"},"content":{"rendered":"

Depression, in\u00a0psychology, is a mood or emotional state marked by feelings of low self-worth or guilt and a reduced ability to enjoy life. A person who is depressed usually experiences several of the following symptoms: feelings of sadness, hopelessness, or pessimism; lowered self-esteem and heightened self-depreciation; a decrease or loss of ability to take pleasure in ordinary activities; reduced energy and vitality; slowness of thought or action; loss of\u00a0appetite; and disturbed\u00a0sleep\u00a0or\u00a0insomnia\u00a0[1]<\/strong>.<\/p>\n

 <\/p>\n

Symptoms<\/strong><\/p>\n

Depression symptoms can vary from mild to severe and can include:<\/p>\n

1.\u00a0<\/strong>Feeling sad or having a depressed mood<\/p>\n

2.<\/strong>\u00a0Loss of interest or pleasure in activities once enjoyed<\/p>\n

3.<\/strong>\u00a0Changes in appetite, weight loss or gain unrelated to dieting<\/p>\n

4.<\/strong>\u00a0Trouble sleeping or sleeping too much<\/p>\n

5.<\/strong>\u00a0Loss of energy or increased fatigue<\/p>\n

6.<\/strong>\u00a0Increase in purposeless physical activity (e.g., hand-wringing or pacing) or slowed movements and speech (actions observable by others)<\/p>\n

7.\u00a0<\/strong>Feeling worthless or guilty<\/p>\n

8.<\/strong>\u00a0Difficulty thinking, concentrating or making decisions<\/p>\n

9.\u00a0<\/strong>Thoughts of death or suicide\u00a0[2]<\/strong>.<\/p>\n

Risk Factors for Depression<\/strong><\/p>\n

Depression can affect anyone\uff0ceven a person who appears to live in relatively ideal circumstances.<\/p>\n

Several factors can play a role in depression:<\/p>\n

1.\u00a0<\/strong>Biochemistry:\u00a0Differences in certain chemicals in the brain may contribute to symptoms of depression.<\/p>\n

2.\u00a0<\/strong>Genetics:\u00a0Depression can run in families. For example, if one identical twin has depression, the other has a 70 percent chance of having the illness sometime in life.<\/p>\n

3.\u00a0<\/strong>Personality:\u00a0People with low self-esteem, who are easily overwhelmed by stress, or who are generally pessimistic appear to be more likely to experience depression.<\/p>\n

4.<\/strong>\u00a0Environmental factors:\u00a0Continuous exposure to violence, neglect, abuse or poverty may make some people more vulnerable to depression\u00a0[3]<\/strong>.<\/p>\n

Treatment<\/strong><\/p>\n

Depressions that are more biological in their origins (melancholic depression and psychotic depression) are more likely to need physical treatments (antidepressants) and less likely to be resolved with psychological treatments alone. Non-melancholic depression which is linked to psychological factors, personality characteristics and stressful life events, responds to both psychological treatments and physical treatments.<\/p>\n

A.\u00a0 Physical treatments.<\/strong><\/p>\n

The main physical treatments for depression comprise drug treatments and Electroconvulsive therapy (ECT).<\/p>\n

1.<\/strong>\u00a0Medications\u00a0<\/strong><\/p>\n

There are three groups of drugs most likely to be used for depression:<\/p>\n

1)\u00a0<\/strong>Tranquillisers<\/p>\n

2)\u00a0<\/strong>Antidepressants<\/p>\n

3)<\/strong>\u00a0Mood stabilizers<\/p>\n

2. Electroconvulsive Therapy (ECT)<\/strong><\/p>\n

Because of its controversial past many people feel the need to think carefully before having ECT or allowing it to be given to relatives. Clinicians at the Institute firmly believe that ECT has a small but important role in treatment, particularly in cases of:<\/p>\n

1)\u00a0<\/strong>\u00a0Psychotic depression<\/p>\n

2)<\/strong>\u00a0severe melancholic depression where there is a high risk of suicide or the patient is too ill to eat, drink or take medications\uff0e<\/p>\n

3)\u00a0<\/strong>Life-threatening mania<\/p>\n

4)<\/strong>\u00a0Severe post-natal depression.<\/p>\n

B. Psychological treatments<\/strong><\/p>\n

There are a wide range of psychological treatments for depression. The main ones include:<\/p>\n

1)<\/strong>\u00a0cognitive behavior therapy (CBT)<\/p>\n

2)<\/strong>\u00a0Mindfulness meditation \u2022 interpersonal therapy (IPT)<\/p>\n

3)<\/strong>\u00a0Psychotherapy<\/p>\n

4)\u00a0<\/strong>Counselling.<\/p>\n

C. Self-help and alternative therapies<\/strong><\/p>\n

There are also a wide range of self-help measures and alternate therapies which can be useful for some types of depression, either alone or in\u3000conjunction with physical treatments (such as antidepressants) or psychological treatments. The more biological types of depression (melancholic and psychotic depression) are very unlikely to respond to self-help and alternative therapies alone. However, these therapies can be valuable adjuncts to physical treatments. Self-help and alternative therapies that may be useful for depression are:<\/p>\n

1)\u00a0<\/strong>Meditation<\/p>\n

2)<\/strong>\u00a0Relaxation and meditation techniques<\/p>\n

3)\u00a0<\/strong>Good nutrition \u2022 alcohol and drug avoidance<\/p>\n

4)<\/strong>\u00a0Exercise<\/p>\n

5)<\/strong>\u00a0Bibliotherapy<\/p>\n

6)<\/strong>\u00a0Omega-3<\/p>\n

7)<\/strong>\u00a0Light therapy<\/p>\n

8)<\/strong>\u00a0Yoga<\/p>\n

9)\u00a0<\/strong>Acupuncture.<\/p>\n

10)<\/strong>\u00a0St John’s wort\uff3fSt John’s wort is a herbal treatment that some people take for depression\u00a0[4]<\/strong>.<\/p>\n

Research work<\/strong><\/p>\n

Trials are looking at the effects of\u00a0botulinum toxins\u00a0on depression. The idea is that the drug is used to make the person look less frowning and that this stops the negative\u00a0facial feedback\u00a0from the face. In 2015 results showed, however, that the partly positive effects that had been observed until then could have been due to\u00a0placebo\u00a0effects\u00a0[5].<\/p>\n

MRI\u00a0scans of patients with depression have revealed a number of differences in brain structure compared to those who are not depressed. Meta-analyses of\u00a0neuroimaging\u00a0studies in major depression reported that, compared to controls, depressed patients had increased volume of the\u00a0lateral ventricles\u00a0and\u00a0adrenal gland\u00a0and smaller volumes of the\u00a0basal ganglia,\u00a0thalamus,\u00a0hippocampus, and\u00a0frontal lobe\u00a0(including the\u00a0orbitofrontal cortex\u00a0and\u00a0gyrus rectus)\u00a0[6].\u00a0Hyperintensities\u00a0have been associated with patients with a late age of onset, and have led to the development of the theory of\u00a0vascular depression\u00a0[7].<\/p>\n

References<\/strong><\/p>\n

1. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). American Psychiatric Association. 2013.<\/p>\n

2. Depression. National Institute of Mental Health (NIMH). Retrieved 7 September 2008<\/p>\n

3. Iyer, K., & Khan, Z. A. Review Paper Depression\u2013A Review. Research Journal of Recent Sciences, Vol. 1(4), 79-87, April (2012)<\/p>\n

4. https:\/\/blackdoginstitute.org.au\/docs\/defaultsource\/factsheets\/treatmentsfordepression.pdf<\/p>\n

5. Milev, R. (2015). Response of depression to botulinum toxin treatment: agitation as a predictor. Frontiers in psychiatry, 6, 55.<\/p>\n

6. Arnone, D., McIntosh, A. M., Ebmeier, K. P., Munaf\u00f2, M. R., & Anderson, I. M. (2012). Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. European Neuropsychopharmacology, 22(1), 1-16.<\/p>\n

7. Herrmann, L. L., Le Masurier, M., & Ebmeier, K. P. (2008). White matter hyperintensities in late life depression: a systematic review. Journal of Neurology, Neurosurgery & Psychiatry, 79(6), 619-624.<\/p>\n","protected":false},"excerpt":{"rendered":"

Depression, in\u00a0psychology, is a mood or emotional state marked by feelings of low self-worth or guilt and a reduced ability to enjoy life. A person who is depressed usually experiences several of the following symptoms: feelings of sadness, hopelessness, or<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,14],"tags":[477,186],"class_list":["post-4639","post","type-post","status-publish","format-standard","hentry","category-general-information","category-neuroscience","tag-elabscience","tag-neuroscience"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/4639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=4639"}],"version-history":[{"count":13,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/4639\/revisions"}],"predecessor-version":[{"id":5077,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/4639\/revisions\/5077"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=4639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=4639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=4639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}