{"id":5164,"date":"2019-08-14T09:49:23","date_gmt":"2019-08-14T09:49:23","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=5164"},"modified":"2024-04-17T11:59:18","modified_gmt":"2024-04-17T11:59:18","slug":"the-use-of-immunotherapy-in-treating-hhv-6-infection","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/the-use-of-immunotherapy-in-treating-hhv-6-infection\/","title":{"rendered":"The Use of Immunotherapy in Treating HHV-6 Infection"},"content":{"rendered":"

Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection. HHV-6B reactivation occurs in its immunocompromised host (e.g. patients receiving allogeneic hematopoietic stem cell or solid-organ transplantation and AIDS patients) and causes severe complications.<\/p>\n

Recently, there have been notable advances in defining T-cell responses specific to HHV-6 and in developing approaches to adoptive immunotherapy. By enhancing the body\u2019s immune response to the pathogen, it is thought the virus will have less ability to live and progress.<\/p>\n

Monitoring of HHV-6B-specific T-cells using MHC Tetramers<\/a> is useful for understanding of these T-cell responses. MHC Tetramers can detect T-cells specific to HHV-6 and measure the effectiveness of immunotherapy candidates. Those candidates that increase the immune response could become future immunotherapy treatments.<\/p>\n

Product Highlights<\/h3>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t
Cat. No.<\/th> Product Name<\/th>\n<\/tr>\n<\/thead>\n
TS-M143-1<\/a><\/td>HLA-A*02:01 HHV-6B U54 Tetramer-ILYGPLTRI-PE<\/td>\n<\/tr>\n
TS-M143-2<\/a><\/td>HLA-A*02:01 HHV-6B U54 Tetramer-ILYGPLTRI-APC<\/td>\n<\/tr>\n
TS-M164-1<\/a><\/td> HLA-A*24:02 HHV-6B U54 Tetramer-PFHCSFHTI-PE<\/td>\n<\/tr>\n
TS-M164-2<\/a><\/td> HLA-A*24:02 HHV-6B U54 Tetramer-PFHCSFHTI-APC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

 <\/p>\n

Superior Specificity with MBLI Tetramers<\/strong><\/h4>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\u2022 White Paper: Analysis of neoantigen-reactive T cells using the QuickSwitch™ custom tetramer\u00a0 \u00a0 kit<\/a>
\n\u2022 Evaluating the biological activity of a cancer vaccine with the HLA-A*02:01 QuickSwitch™\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Quant platform<\/a>
\n\u2022 New Alleles added to the MHC Class I Tetramer Range<\/a>
\n\u2022 Class II MHC Tetramers Available from MBL International<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection.<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[67],"class_list":["post-5164","post","type-post","status-publish","format-standard","hentry","category-tetramer","tag-mbl-international"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=5164"}],"version-history":[{"count":8,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5164\/revisions"}],"predecessor-version":[{"id":5691,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5164\/revisions\/5691"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=5164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=5164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=5164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}