{"id":5371,"date":"2019-10-22T09:06:56","date_gmt":"2019-10-22T09:06:56","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=5371"},"modified":"2022-03-10T13:40:42","modified_gmt":"2022-03-10T13:40:42","slug":"extracellular-vesicles-containing-enampt-extend-lifespan","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/extracellular-vesicles-containing-enampt-extend-lifespan\/","title":{"rendered":"Extracellular Vesicles Containing eNAMPT Extend Lifespan"},"content":{"rendered":"

A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice and humans. When overexpressed eNAMPT increases NAD+ levels in multiple tissues, enhances their function and extends lifespan of mice. The majority of eNAMPT found in serum\/plasma circulates in extracellular vesicles (EVs) and it is a necessity for eNAMPT to be in EVs to act on target cells. Detection of eNAMPT in this study is performed by western blotting using Adipogen Life Sciences\u2019 monoclonal antibody anti-Nampt (Visfatin\/PBEF), mAb (OMNI379) (Prod. No. AG-20A-0034<\/a>).<\/p>\n

AdipoGen Life Sciences provides best reagents to study NAMPT in vitro and in vivo in human or mouse:<\/h3>\n

– Nampt (Visfatin\/PBEF) (human) (rec.) (Prod. No. AG-40A-0031Y<\/a>)<\/p>\n

– Nampt (Visfatin\/PBEF) (mouse) (rec.) (Prod. No. AG-40A-0056Y<\/a>)<\/p>\n

– Nampt (Visfatin\/PBEF) (rat) (rec.) (Prod. No. AG-40A-0058<\/a>)<\/p>\n

– Nampt (Visfatin\/PBEF) (human) ELISA Kit (Prod. No. AG-45A-0006Y<\/a>)<\/p>\n

– Nampt (Visfatin\/PBEF) (mouse\/rat) Dual ELISA Kit (Prod. No. AG-45A-0007Y)<\/a><\/p>\n

LIT: Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice: M. Yoshida, et al.; Cell Metabol. (ePub ahead of print) (2019)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[279],"class_list":["post-5371","post","type-post","status-publish","format-standard","hentry","category-general-information","tag-adipogen"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=5371"}],"version-history":[{"count":3,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5371\/revisions"}],"predecessor-version":[{"id":5667,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/5371\/revisions\/5667"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=5371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=5371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=5371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}