Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance between erythroid and myeloid differentiation during hematopoiesis. Activation of the inflammasome and caspase-1 results in the cleavage of the master erythroid transcription factor GATA1, with a decrease in erythrocyte differentiation and in the increase of myeloid cell differentiation.<\/p>\n
– anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Prod. No. AG-20B-0042<\/a>)<\/p>\n – anti-Caspase-1 (p20) (human), mAb (Bally-1) (Prod. No. AG-20B-0048<\/a>)<\/p>\n – anti-NLRP3\/NALP3, mAb (Cryo-2) (Prod. No. AG-20B-0014<\/a>)<\/p>\n – anti-Asc, pAb (AL177) (Prod. No. AG-25B-0006<\/a>)<\/p>\n – anti-Caspase-4 \/11 (p20), mAb (Flamy-1) (Prod. No. AG-20B-0060<\/a>)<\/p>\n – anti-NLRP6\/NALP6 (human), mAb (Clint-1) (Prod. No. AG-20B-0046<\/a>)<\/p>\n – MCC950 . sodium salt [NLRP3 Inhibitor] (Prod. No. AG-CR1-3615<\/a>)<\/p>\n – Monosodium urate (ready-to-use) [NLRP3 Activator] (Prod. No. AG-CR1-3951<\/a>)<\/p>\n