{"id":6416,"date":"2021-09-21T12:18:09","date_gmt":"2021-09-21T12:18:09","guid":{"rendered":"http:\/\/www.caltagmedsystems.co.uk\/information\/?p=6416"},"modified":"2022-03-10T12:26:17","modified_gmt":"2022-03-10T12:26:17","slug":"cellvo-cells-from-stembiosys","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/cellvo-cells-from-stembiosys\/","title":{"rendered":"CELLvo Cells from StemBioSys"},"content":{"rendered":"

\"StemBioSys<\/a>CELLvo™ cells from StemBioSys<\/a> are the only cells isolated and expanded using StemBioSys\u2019s CELLvo™ Matrix technology<\/a>. By isolating cells on a cell-derived extracellular matrix (ECM), StemBiosys are able to preserve more natural phenotypes. Cells are always isolated from the best possible quality of tissue, are early-passage and xeno-free whenever possible, providing the best possible cells for your research.<\/p>\n

Caltag Medsystems are the UK and European distributor for StemBioSys. Contact us today, or read on to learn what makes StemBioSys’s CELLvo cells different…<\/p>\n

Advantages of CELLvo Cells<\/h1>\n

Young Donor Populations<\/h2>\n

Many cell providers compromise the quality of their cells by using primary cells from elderly, obese, or sick donors due to the difficulty of finding healthy tissue sources. StemBioSys source all of their cells from young, healthy tissue to ensure our customers have top quality cells.<\/p>\n

\"Image<\/a><\/p>\n

Image from paper<\/a> on the rescue of aging stem cells showing the pro-inflammatory cytokine profile of elderly MSCs. It is important to get cells from healthy donors to get normal function.<\/em><\/p>\n

Unique, Difficult to Isolate Cells<\/h2>\n

The CELLvo™ Matrix technology enables StemBioSys to efficiently isolate rare populations of cells that are difficult to isolate with other culture methods. For example, the CELLvo endothelial progenitor cells<\/a>, are rare, highly angiogenic cells found in umbilical cord blood. Through use the CELLvo™ Matrix, StemBioSys can isolate and expand these cells whilst maintaining their phenotype.<\/p>\n

\"CELLvo™<\/a><\/p>\n

CELLvo™ Cord Blood Endothelial Progenitor Cells (hCB-EPC) (100x). These are rare cells that are highly proliferative and highly angiogenic when isolated and grown on CELLvo™ Matrix.<\/em><\/p>\n

Cells That Have Never Seen Plastic<\/h2>\n

Cells respond to their environment with changes in their gene expression. In many cases, these changes may be difficult to reverse. StemBiosys isolate and expand their cell products on CELLvo™ Matrix technology in order to maintain a more natural phenotype, relative to cells isolated on simple substrates.<\/p>\n

\"Image<\/a><\/p>\n

Image courtesy of Robert Mecham. Freeze fracture image of cell surrounded by extracellular matrix in native tissue. In vivo, cells are constantly receiving signals from the surrounding matrix.<\/em><\/p>\n

Biologically-Relevant Phenotypes<\/h2>\n

StemBiosys only sell freshly isolated cells or early-passage cells that have been isolated and expanded on CELLvo™ Matrix to maintain a more natural phenotype. Certain cell types will no longer resemble the native population if they are passaged too far. For instance, only CELLvo™ Primary Chondrocytes<\/a> exhibit the high Col2\/Col1 ratio that is found in native cartilage, where as highly passaged \u201cchondrocytes\u201d no longer look like anything you can find in the body.<\/p>\n

\"Col2\/Col1<\/a><\/p>\n

Col2\/Col1 ratio of commercially available chondrocytes. Only CELLvo™ Primary Chondrocytes from StemBioSys\u00ae have a high Col2\/Col1 ratio, like that observed in cartilage. (Data available at StemBioSys).<\/em><\/p>\n

Xeno-Free Products<\/h2>\n

As part StemBioSys’s commitment to providing the most biologically-relevant tools to their customers, research, development, and manufacturing all occur \u00a0xeno-free whenever possible. All\u00a0 mesenchymal stem cell products are isolated and cryopreserved in 100% xeno-free conditions meaning cells that have never come in contact with non-human proteins. We recommend the use of CELLvo™ XF Matrix<\/a> for the continued xeno-free culture of these cells.<\/p>\n

CELLvo Human Mesenchymal Stem Cells<\/h1>\n

StemBioSys isolates and expands mesenchymal stem cells (MSCs) from a variety of human tissues for sale to the research market. All of their MSCs are sourced from young donor material, and isolated in xeno-free conditions on CELLvo™ XF Matrix<\/a> so that they never come in contact with foreign materials and maintain a biologically-relevant phenotype. StemBioSys is committed to providing our customers with the highest quality human mesenchymal stem cells on the market.<\/p>\n

NEW: CELLvo™ Amniotic Membrane-Mesenchymal Stem Cells<\/h2>\n

\u2022 Enzymatically isolated
\n\u2022 Available at passage 2
\n\u2022 Expanded on CELLvo™ XF Matrix<\/p>\n

\"\"<\/a><\/p>\n

Isolated from the amniotic membrane of full-term pregnancies delivered by Caesarean section, CELLvo™ Amniotic Membrane Mesenchymal Stem Cells are expanded without the use of animal products.<\/p>\n

Rigorous quality control confirms cell identity by testing for the expression of surface and intracellular markers. The cells are also tested for their ability to undergo adipogenic and osteogenic differentiation.<\/p>\n

CELLvo™ Amniotic Membrane Mesenchymal Stem Cells (AM-MSCs) are known for their ability to promote angiogenesis and neurogenesis and their potential to attenuate graft-vs-host disease.<\/p>\n

CELLvo™ AM-MSCs are available through Caltag Medsystems.<\/p>\n

Contact us<\/a> for details<\/p>\n

CELLvo™ Human Bone Marrow Mesenchymal Stem Cells<\/h2>\n

\"CELLvo™<\/a><\/p>\n

CELLvo™ hBM-MSCs have been isolated and cultured under xeno-free conditions on the CELLvo™ XF Matrix. These cells proliferate more quickly, have a smaller cell size and show a higher percentage of SSEA4 (+) cells as compared to BM-MSCs isolated and cultured on other substrates.<\/p>\n

View all products<\/a><\/p>\n

CELLvo™ Human Adipose Mesenchymal Stem Cells<\/h2>\n

\"CELLvo™<\/a><\/p>\n

hAD-MSCs are multipotent stem cells, capable of rapid proliferation, tri-lineage differentiation, and potent immunomodulation, found in abundance in the stromal vascular fraction of adipose tissue. Currently, adipose tissue is the most common source of MSCs in clinical use.<\/p>\n

CELLvo™ Adipose Derived Mesenchymal Stem Cells (hAD-MSC) are isolated and cultured under xeno-free conditions on the CELLvo™ XF Matrix. CELLvo™ hAD-MSCs proliferate more quickly, have a smaller cell size, and show a higher percentage of SSEA4 (+) cells as compared to Adipose Derived MSCs isolated and cultured on other substrates.<\/p>\n

View all products<\/a><\/p>\n

CELLvo™ Human Wharton’s Jelly Mesenchymal Stem Cells<\/h2>\n

\"CELLvo™<\/a><\/p>\n

Wharton\u2019s Jelly is a rich source of highly proliferative, multipotent, Mesenchymal Stem Cells. These cells are known to be highly immunomodulatory and capable of trilineage di\ufb00erentiation.<\/p>\n

CELLvo™ human Mesenchymal Stem Cells \u2013 Wharton\u2019s Jelly (MSC-WJ) are isolated and cultured under xeno-free conditions on the CELLvo™ XF Matrix. CELLvo™ MSC-WJ proliferate more quickly, have a smaller cell size, and show a higher percentage of SSEA4 (+) cells as compared to Wharton\u2019s Jelly MSCs isolated and cultured on other substrates.<\/p>\n

View all products<\/a><\/p>\n

Human Chondrocytes<\/h1>\n

StemBioSys offer a range of human chondrocytes, from young, healthy cells at early passage, or older, uncultured osteoarthritic cells.<\/p>\n

This range of products allows for a deeper understanding of authentic chondrocyte behavior. To compare healthy and diseased chondrocytes, or expand chondrocyte cultures while maintaining potency and natural phenotype with reduced de-differentiation.<\/p>\n

CELLvo™ Human Chondrocytes (<40y)<\/strong> are mature, primary cells sourced from young individuals. They may be selected as uncultured (P0), or isolated and expanded on CELLvo™ Matrix.<\/p>\n

CELLvo™ Healthy Human Chondrocytes (50-70y)<\/strong> are primary cells, sourced from healthy individuals 50 to 70-years old and verified free of osteoarthritis. Cells are supplied as uncultured (P0).<\/p>\n

CELLvo™ Osteoarthritic Human Chondrocytes (50-70y)<\/strong> are primary cells, sourced from osteoarthritic individuals 50 to 70-years old. Cells are supplied as uncultured (P0).<\/p>\n

View all products<\/a><\/p>\n

CELLvo™ Human Endothelial Progenitor Cells<\/h2>\n

\"CELLvo™<\/a><\/p>\n

CELLvo™ hCB-EPCs cells are progenitors of other endothelial type cells. These cells exhibit superior colony forming abilities, greater vessel formation, and greater angiogenic potential in vitro as well as in vivo \u2013 as compared to hUVECs. CELLvo™ hCB-EPCs cells are the cell of choice for researchers wanting greater control of their endothelial culture related studies. When grown on the CELLvo™ Matrix, CELLvo™ hCB-EPCs behave more naturally, allowing researchers greater control of their study.<\/p>\n

Download the CELLvo™ EPC Whitepaper:
\nCELLvo™ Human Cord Blood-Endothelial Progenitor Cells are Highly Proliferative and Angiogenic<\/a><\/p>\n

View all products<\/a><\/p>\n

Further Information<\/h1>\n

If you have any questions about any of the products in this post, please contact us<\/a> for more information. StemBioSys products are distributed in the UK and Europe by Caltag Medsystems.<\/p>\n","protected":false},"excerpt":{"rendered":"

CELLvo™ cells from StemBioSys are the only cells isolated and expanded using StemBioSys\u2019s CELLvo™ Matrix technology. By isolating cells on a cell-derived extracellular matrix (ECM), StemBiosys are able to preserve more natural phenotypes. Cells are always isolated from the best<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18,45,474],"tags":[81,548,561,562,560,540],"class_list":["post-6416","post","type-post","status-publish","format-standard","hentry","category-cell-culture","category-stem-cells","category-stem-cells-2","tag-cell-culture","tag-cellvo","tag-chondrocytes","tag-matrix","tag-mcss","tag-stembiosys"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/6416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=6416"}],"version-history":[{"count":12,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/6416\/revisions"}],"predecessor-version":[{"id":6525,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/6416\/revisions\/6525"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=6416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=6416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=6416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}