{"id":7022,"date":"2022-11-11T11:31:16","date_gmt":"2022-11-11T11:31:16","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=7022"},"modified":"2023-08-03T11:36:32","modified_gmt":"2023-08-03T11:36:32","slug":"new-ace2-human-elisa-kit","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/new-ace2-human-elisa-kit\/","title":{"rendered":"New ACE2 (human) ELISA Kit"},"content":{"rendered":"\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/www.caltagmedsystems.co.uk\/adipogen\/\" target=\"_blank\">AdipoGen Life Sciences<\/a> has developed a sensitive and specific colourimetric sandwich ACE2 (human) ELISA Kit (Prod. No. <a rel=\"noreferrer noopener\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/product_detail.php?CI_ID=1189572&amp;group_1=All&amp;group_2=All&amp;supplier=All&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;searchwords=AG-45B-0023\" target=\"_blank\">AG-45B-0023<\/a>) that can be used for the in vitro quantitative determination of soluble human ACE2 in cell culture supernatants, serum, plasma and urine.<\/p>\n\n\n\n<p>ACE2 has been identified as a key receptor on target cells for SARS-CoV infections in 2002. ACE2 functions as the entry receptor of the new SARS-CoV-2 coronavirus that emerged in China in 2019 and is the cause of the new disease COVID-19. Strong binding of the spike protein of SARS-CoV-2 to ACE2, along with proteolytic cleavage of ACE2 by transmembrane serine protease 2 (TMPRSS2), facilitates entry of the virus into cells, viral replication and cell-to-cell transmission. ACE2 can undergo an ADAM17 (a disintegrin and metalloproteinase 17)-mediated \u201cshedding\u201d from endothelial cells, resulting in the release of the ectodomain into the circulation. This soluble form may act as a competitive interceptor of SARS-CoV-2 and other coronaviruses by preventing the binding of the viral particle to the surface-bound, full-length ACE2. A reliable ELISA Kit to determine soluble ACE2 in the circulation can be useful in therapeutic developmental studies.<\/p>\n\n\n\n<p>Soluble ACE2 might also be used as a biomarker of hypertension and cardiovascular diseases.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/ag-45b-0023-standard_curve-400-Adiopgen-2.png\"><img loading=\"lazy\" decoding=\"async\" width=\"430\" height=\"388\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/ag-45b-0023-standard_curve-400-Adiopgen-2.png\" alt=\"\" class=\"wp-image-7030\" srcset=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/ag-45b-0023-standard_curve-400-Adiopgen-2.png 430w, https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/ag-45b-0023-standard_curve-400-Adiopgen-2-300x271.png 300w\" sizes=\"auto, (max-width: 430px) 100vw, 430px\" \/><\/a><figcaption class=\"wp-element-caption\">Figure: Typical Standard Curve<\/figcaption><\/figure>\n\n\n\n<p class=\"clear\">Originally posted on&nbsp;<a href=\"https:\/\/adipogen.com\/covid-19\">adipogen.com\/covid-19<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.caltagmedsystems.co.uk\/\">Caltag Medsystems&nbsp;<\/a>is the distributor of&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/adipogen\/\">Adipogen<\/a>&nbsp;products in the UK and Ireland. If you have any questions about these products, please&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">contact<\/a>&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adipogen has developed a sensitive and specific colourimetric sandwich ACE2 (human) ELISA Kit.<\/p>\n","protected":false},"author":12,"featured_media":7872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[517,102],"tags":[279,515,8],"class_list":["post-7022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-elisa","tag-adipogen","tag-covid-19","tag-elisa"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/7022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=7022"}],"version-history":[{"count":6,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/7022\/revisions"}],"predecessor-version":[{"id":7880,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/7022\/revisions\/7880"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/7872"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=7022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=7022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=7022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}