{"id":8147,"date":"2023-08-04T11:18:39","date_gmt":"2023-08-04T11:18:39","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=8147"},"modified":"2023-08-04T11:18:39","modified_gmt":"2023-08-04T11:18:39","slug":"gitr-gitrl-pathway","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/gitr-gitrl-pathway\/","title":{"rendered":"GITR \u2013 GITRL Pathway"},"content":{"rendered":"\n
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Glucocorticoid-induced TNFR-related protein (GITR; CD357; TNFRSF18) is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL (TNFSF18). Once exposure to tumour antigen activates a T cell, the number of GITR receptors on its surface increases. On the activated T cell, GITR acts as a co-stimulatory receptor, meaning that it is a receptor whose signalling enhances cell reproduction and the generation of cancer-killing activity. Activation of GITR signalling can also help to enhance immunity through the activation of cytotoxic T cells and inhibition of Treg activity.<\/p>\n\n\n\n

LIT:<\/strong>\u00a0\u00a0Modulation of GITR for cancer immunotherapy: D.A. Schaer, et al.; Curr. Opin. Immunol.\u00a024,<\/strong>\u00a0217 (2012) | Rationale for anti-GITR cancer immunotherapy: D.A. Knee, et al.; Eur. J. Cancer\u00a067,<\/strong>\u00a01 (2016)<\/p>\n\n\n\n

Biologically Active\u00a0GITR and GITRL Proteins<\/strong>\u00a0<\/p>\n\n\n\n

See all Biologically Active\u00a0GITR and GITRL Proteins by AdipoGen Life Sciences\u00a0here<\/a>.<\/p>\n\n\n\n

See all Biologically Active\u00a0GITR and GITRL Proteins by Chimerigen here<\/a>.<\/p>\n\n\n\n

VALIDATED\u00a0Antibodies for GITR and GITRL Research<\/strong><\/p>\n\n\n\n

See all VALIDATED\u00a0Antibodies for GITR and GITRL Research by AdipoGen Life Sciences here<\/a>.<\/p>\n\n\n\n

See all VALIDATED\u00a0Antibodies for GITR and GITRL Research by Ancell here<\/a>.<\/p>\n\n\n\n

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Back to T Cell Immune Checkpoints for Immuno-Oncology Research<\/strong><\/a><\/div>\n<\/div>\n\n\n\n

Originally posted on\u00a0adipogen.com\/gitr-gitrl-pathway\/<\/a><\/p>\n\n\n\n

Caltag Medsystems <\/a>is the distributor of Adipogen<\/a> products in the UK and Ireland. If you have any questions about these products, please contact<\/a> us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.<\/p>\n","protected":false},"author":13,"featured_media":8151,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,1,637],"tags":[279,185,7,683,685],"class_list":["post-8147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-general-information","category-t-cells","tag-adipogen","tag-antibodies","tag-cancer","tag-proteins","tag-t-cells-2"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=8147"}],"version-history":[{"count":3,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8147\/revisions"}],"predecessor-version":[{"id":8154,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8147\/revisions\/8154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/8151"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=8147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=8147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=8147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}