{"id":8155,"date":"2023-08-04T11:31:31","date_gmt":"2023-08-04T11:31:31","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=8155"},"modified":"2023-08-09T12:43:33","modified_gmt":"2023-08-09T12:43:33","slug":"cd40-cd40l-pathway","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/cd40-cd40l-pathway\/","title":{"rendered":"CD40 \u2013 CD40L Pathway"},"content":{"rendered":"\n
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CD40 is a member of the TNF receptor family expressed by antigen-presenting cells (APCs) and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells. Interaction between CD40-CD40L stimulates cytokines secretion of B cells with subsequent T cell activation and antitumour immunity. This T cell priming effect of the CD40-CD40L pathway might be a useful approach in anticancer immunotherapy.<\/p>\n\n\n\n

LIT:<\/strong> Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists: G.L. Beatty, et al.; Expert Rev. Anticancer Ther. 17,<\/strong> 175 (2017) \u2022 Multiple effects of CD40-CD40L axis in immunity against infection and cancer: A. Ara, et al.; Immunotargets Ther. 7,<\/strong> 55 (2018)<\/p>\n\n\n\n

CD40L (human) ELISA Kit  – Biomarker for Autoimmune Diseases & Cancers<\/strong><\/p>\n\n\n\n

The CD40L (human) ELISA Kit (Prod. No. AG-45B-0018<\/a>) is a sandwich ELISA for specific quantitative determination of human soluble CD40L in serum, plasma and cell culture supernatants. This ELISA Kit shows a very high specificity and sensitivity (20pg\/ml).<\/p>\n\n\n\n

B Cell Expansion:  Highly Potent B Cell Activators and T Cell Priming Reagents<\/strong><\/p>\n\n\n\n

CD40 activation tools can be used to expand B cells, which, as antigen-presenting cells (APCs), are as effective as dendritic cells and promises to streamline the generation of antitumour CD8+ T cells. Several studies show that usage of the agonistic anti-CD40 antibody (FGK45) (Prod. No. AG-20B-0036PF<\/a>) and MultimericCD40L (Prod. No. AG-40B-0010<\/a>) are strong stimulators of antitumour immunity.<\/p>\n\n\n\n

LIT:<\/strong> R.S. Kornbluth, et al.; Int. Rev. Immunol. 31,<\/strong> 279 (2012) \u2022 K.T. Byrne & R.H. Vonderheide; Cell Rep. 15,<\/strong> 2719 (2016)<\/p>\n\n\n\n

CD40L (human) (multimeric) (rec.)<\/strong><\/p>\n\n\n\n

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Prod. No. AG-40B-0010<\/a><\/p>\n\n\n\n

Figure: <\/strong>CD40L (human) (multimeric) (rec.) (Prod. No. AG-40B-0010<\/a>) does not need an enhancer to induce B cell activation.<\/p>\n\n\n\n

CD40L (human) (multimeric) (rec.) (Certified Serum Grade)<\/strong><\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Prod. No. AG-40B-0010CSG<\/p>\n\n\n\n

Figure: <\/strong>CD40L (human) (multimeric) (rec.) (Certified Serum Grade) (Prod. No. AG-40B-0010CSG) does not need an enhancer to induce B cell activation.<\/p>\n\n\n\n

anti-CD40 (mouse), mAb (FGK45)<\/strong><\/p>\n\n\n\n

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Prod. No. AG-20B-0036<\/a><\/p>\n\n\n\n

Figure: <\/strong>Systemic immune activation by CD40 ligation. Mice were sacrificed on day 8 after daily treatment on day 4-7 with FGK45 or control. FGK45 treatment elevated splenocyte numbers. *P < 0.005. Data represent mean \u00b1 SD for three to four mice per group.<\/p>\n\n\n\n

Biologically Active CD40 and CD40L Proteins<\/strong><\/p>\n\n\n\n

See all Biologically Active CD40 and CD40L Proteins by AdipoGen Life Sciences here<\/a>.<\/p>\n\n\n\n

See all Biologically Active CD40 and CD40L Proteins by Chimerigen here<\/a>.<\/p>\n\n\n\n

See all Biologically Active CD40 and CD40L Proteins by Ancell here<\/a>.<\/p>\n\n\n\n

VALIDATED Antibodies for CD40 and CD40L Research<\/strong><\/p>\n\n\n\n

See all VALIDATED Antibodies for CD40 and CD40L Research by AdipoGen Life Sciences here<\/a>.<\/p>\n\n\n\n

See all VALIDATED Antibodies for CD40 and CD40L Research by Ancell here<\/a>.<\/p>\n\n\n\n

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Back to T Cell Immune Checkpoints for Immuno-Oncology Research<\/strong><\/a><\/div>\n<\/div>\n\n\n\n

Originally posted on adipogen.com\/cd40-cd40l-pathway\/<\/a><\/p>\n\n\n\n

Caltag Medsystems <\/a>is the distributor of Adipogen<\/a> products in the UK and Ireland. If you have any questions about these products, please contact<\/a> us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

CD40 is a member of the TNF receptor family expressed by APCs and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells.<\/p>\n","protected":false},"author":13,"featured_media":8166,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,1,637],"tags":[279,185,7,683,685],"class_list":["post-8155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-general-information","category-t-cells","tag-adipogen","tag-antibodies","tag-cancer","tag-proteins","tag-t-cells-2"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=8155"}],"version-history":[{"count":8,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8155\/revisions"}],"predecessor-version":[{"id":8282,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8155\/revisions\/8282"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/8166"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=8155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=8155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=8155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}