{"id":8213,"date":"2023-08-04T13:03:37","date_gmt":"2023-08-04T13:03:37","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=8213"},"modified":"2023-08-04T13:03:37","modified_gmt":"2023-08-04T13:03:37","slug":"ox40-ox40l-pathway","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/ox40-ox40l-pathway\/","title":{"rendered":"OX40 \u2013 OX40L Pathway"},"content":{"rendered":"\n
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OX40 (CD134; TNFRSF4) is an activating receptor expressed on the surface of activated cytotoxic T cells and regulatory T cells (Tregs). OX40 plays a dual role in the immune response, both activating and amplifying T cell responses. On cytotoxic T cells, OX40 binds to its ligand OX40L (CD252; TNFSF4), resulting in stimulatory signals that promote T cell reproduction, function and survival. OX40\/OX40L signalling blocks the ability of Tregs to suppress T cells and reduces Treg generation. By inhibiting the immunosuppressive effect of Tregs and limiting their population, OX40 further amplifies the impact of T cell activation. The dual effects of OX40 help to create a tumour microenvironment that is more favourable to the antitumour immune response.<\/p>\n\n\n\n

LIT:<\/strong>\u00a0OX40: Structure and function – What questions remain? J. Willoughby, et al.; Mol. Immunol.\u00a083,<\/strong>\u00a013 (2017) \u2022 The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy: S.L. Buchan, et al.; Blood\u00a0131,<\/strong>\u00a039 (2018)<\/p>\n\n\n\n

Biologically Active\u00a0OX40 and OX40L Proteins<\/strong><\/p>\n\n\n\n

See all Biologically Active\u00a0OX40 and OX40L Proteins\u00a0by AdipoGen Life Sciences here<\/a>.<\/p>\n\n\n\n

See all Biologically Active\u00a0OX40 and OX40L Proteins\u00a0by Chimerigen here<\/a>.<\/p>\n\n\n\n

VALIDATED\u00a0Antibodies for OX40 and OX40L Research<\/strong><\/p>\n\n\n\n

See all VALIDATED\u00a0Antibodies for OX40 and OX40L Research by AdipoGen Life Sciences here<\/a>.<\/p>\n\n\n\n

See all VALIDATED\u00a0Antibodies for OX40 and OX40L Research by Ancell here<\/a>.<\/p>\n\n\n\n

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Back to T Cell Immune Checkpoints for Immuno-Oncology Research<\/strong><\/a><\/div>\n<\/div>\n\n\n\n

Originally posted on\u00a0adipogen.com\/ox40-ox40l-pathway\/<\/a><\/p>\n\n\n\n

Caltag Medsystems <\/a>is the distributor of Adipogen<\/a> products in the UK and Ireland. If you have any questions about these products, please contact<\/a> us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.<\/p>\n","protected":false},"author":13,"featured_media":8215,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,637],"tags":[279,185,7,683,685],"class_list":["post-8213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-t-cells","tag-adipogen","tag-antibodies","tag-cancer","tag-proteins","tag-t-cells-2"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=8213"}],"version-history":[{"count":1,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8213\/revisions"}],"predecessor-version":[{"id":8216,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8213\/revisions\/8216"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/8215"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=8213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=8213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=8213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}