{"id":8299,"date":"2023-08-10T13:04:00","date_gmt":"2023-08-10T13:04:00","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=8299"},"modified":"2023-08-10T13:04:01","modified_gmt":"2023-08-10T13:04:01","slug":"leveraging-anti-integrin-%ce%b1v%ce%b26-antibodies-for-ulcerative-colitis","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/leveraging-anti-integrin-%ce%b1v%ce%b26-antibodies-for-ulcerative-colitis\/","title":{"rendered":"Leveraging Anti-Integrin \u03b1v\u03b26 Antibodies for Ulcerative Colitis"},"content":{"rendered":"\n

Integrins are heterodimeric cell surface receptors involved in cell-extracellular matrix and cell-cell adhesion. In addition, integrins convey two-way signalling between cells and their surroundings and participate in the regulation of a variety of cellular processes, including cell proliferation, migration, survival, tissue invasion, and innate immunity. Mammalian cells have 18 distinct integrin \u03b1 subunits and 8 \u03b2 subunits, which can combine in various ways to form 24 different receptor heterodimers. Integrin \u03b1v\u03b26 is expressed exclusively by epithelial cells and functions as a receptor for extracellular matrix proteins such as fibronectin. Furthermore, integrin \u03b1v\u03b26 expressed in the intestinal epithelium is involved in the suppression of inflammation and prevention of pathogen and parasite infection [1]. Anti-integrin \u03b1v\u03b26 antibodies have been detected in the vast majority of patients with ulcerative colitis, and its titers have been reported to correlate with disease activity [2].<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/a>For more information about the discovery of this kit, please\u00a0read this article<\/a>\u00a0featuring Dr. Shiokawa and Dr. Kuwada.<\/p>\n\n\n\n

MBLI is proud to introduce the Anti-Integrin \u03b1v\u03b26 ELISA Kit that readily allows measurement of anti-integrin \u03b1v\u03b26 antibody levels in human serum.<\/strong><\/p>\n\n\n\n

Product Code<\/strong><\/td>Product Name<\/strong> <\/td><\/tr>
5288<\/a><\/strong><\/td>Anti-Integrin \u03b1v\u03b26 ELISA Kit<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

REFERENCES:<\/p>\n\n\n\n

1. Koivisto L, Bi J, H\u00e4kkinen L, Larjava H. Integrin \u03b1v\u03b26: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018 Jun;99:186-196. doi: 10.1016\/j.biocel.2018.04.013. Epub 2018 Apr 18. PMID: 29678785.

2. Kuwada T, et al. Identification of an Anti-Integrin \u03b1v\u03b26 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021 Jun;160(7):2383-2394.e21. doi: 10.1053\/j.gastro.2021.02.019. Epub 2021 Feb 12. PMID: 33582126.<\/p>\n\n\n\n

Information received from MBL International.<\/p>\n\n\n\n

Caltag Medsystems <\/a>is the distributor of MBL International<\/a> products in the UK and Ireland. If you have any questions about these products, please contact us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

MBLI is proud to introduce the Anti-Integrin \u03b1v\u03b26 ELISA Kit that readily allows measurement of anti-integrin \u03b1v\u03b26 antibody levels in human serum.<\/p>\n","protected":false},"author":13,"featured_media":8306,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[132,1],"tags":[694,695,67,696],"class_list":["post-8299","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antibodies","category-general-information","tag-anti-integrin","tag-avb6","tag-mbl-international","tag-ulcerative-colitis"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=8299"}],"version-history":[{"count":6,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8299\/revisions"}],"predecessor-version":[{"id":8307,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8299\/revisions\/8307"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/8306"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=8299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=8299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=8299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}