{"id":8683,"date":"2023-09-25T10:18:46","date_gmt":"2023-09-25T10:18:46","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=8683"},"modified":"2023-09-25T10:18:46","modified_gmt":"2023-09-25T10:18:46","slug":"histone-deacetylase-hdac-important-consideration-in-regulating-gene-expression","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/histone-deacetylase-hdac-important-consideration-in-regulating-gene-expression\/","title":{"rendered":"Histone deacetylase (HDAC): important consideration in regulating gene expression"},"content":{"rendered":"\n
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Histone deacetylase (HDAC) <\/strong>plays a pivotal role in the regulation of gene expression through the modification of nucleosome structure. Additionally, HDAC is involved in controlling the cell cycle and promoting cellular differentiation. Extensive studies have shown that dysregulation of HDAC can contribute to the development of specific types of cancer. In laboratory experiments, HDAC inhibitors such as trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) have proven their ability to induce differentiation and\/or apoptosis of transformed cells, effectively inhibiting tumour growth in mice.<\/p>\n<\/div><\/div>\n\n\n\n

Medical research has highlighted the effectiveness of HDAC inhibitors in treating acute promyelocytic leukaemia (APL) and various other cancers. Consequently, HDAC inhibitors hold immense potential as innovative anti-tumour drugs and potential antibacterial agents. The screening of histone deacetylase inhibitors is expected to increase in the future as a means of discovering additional compounds with similar properties.<\/p>\n\n\n\n

The CycLex HDACs Deacetylase Fluorometric Assay Kit<\/a><\/strong> is designed to accurately measure the activity of HDAC by converting it into protease activity. This innovative method allows for easy and cost-effective measurement of HDAC activity. This breakthrough measurement technique is expected to significantly enhance the efficiency of inhibitor screening and biochemical analysis of these enzymes.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n
Product Code<\/strong><\/td>Product Name<\/strong> <\/td><\/tr>
CY-1150V2<\/a><\/strong><\/td>CycLex\u00ae HDACs Deacetylase Fluorometric Assay Kit Ver.2<\/td><\/tr>
CY-1158V2<\/a><\/strong><\/td>CycLex\u00ae HDAC8 Deacetylase Fluorometric Assay Kit Ver.2<\/td><\/tr>
CY-1151V2<\/a><\/strong><\/td>CycLex\u00ae SIRT1\/Sir2 Deacetylase Fluorometric Assay Kit Ver.2<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Information provided by MBL<\/a>.<\/p>\n\n\n\n

Caltag Medsystems <\/a>is the distributor of MBL <\/a>products in the UK and Ireland. If you have any questions about these products, please contact us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Histone deacetylase (HDAC) plays a pivotal role in the regulation of gene expression through the modification of nucleosome structure.<\/p>\n","protected":false},"author":13,"featured_media":8691,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[115,718,10,1],"tags":[484,7,299,719,67],"class_list":["post-8683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-apoptosis","category-assay-kit","category-cancer","category-general-information","tag-assay-kit","tag-cancer","tag-gene-expression","tag-hdac","tag-mbl-international"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=8683"}],"version-history":[{"count":6,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8683\/revisions"}],"predecessor-version":[{"id":8692,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/8683\/revisions\/8692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/8691"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=8683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=8683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=8683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}