{"id":9909,"date":"2024-04-18T10:37:40","date_gmt":"2024-04-18T10:37:40","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=9909"},"modified":"2024-04-18T10:37:40","modified_gmt":"2024-04-18T10:37:40","slug":"transfection-reagents-for-in-vivo-delivery","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/transfection-reagents-for-in-vivo-delivery\/","title":{"rendered":"Transfection Reagents for In Vivo Delivery"},"content":{"rendered":"\n

Reagents based on MagnetofectionTM<\/sup>:<\/h2>\n\n\n\n

For General Transfection:<\/h2>\n\n\n\n

In Vivo<\/em> DogtorMagTM<\/sup><\/h3>\n\n\n\n

In vivo<\/em>\u00a0DogtorMag\u2122 <\/strong>Transfection Reagent\u00a0has been designed for\u00a0in vivo<\/em>\u00a0targeted transfection of various types of nucleic acids such as DNA, RNA, and oligonucleotides using magnetic nanoparticles coated with synthetic lipids (In vivo<\/em>\u00a0DogtorMag). DNA complexes can be easily administrated through various injection routes such as systemic administration (intravenous, intra-artery) or local administration (intratumoral, intracerebroventricular).<\/p>\n\n\n\n

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See all in vivo<\/em> DogtorMagTM<\/sup><\/a><\/div>\n<\/div>\n\n\n\n

In Vivo<\/em> PolyMagTM<\/sup><\/h3>\n\n\n\n

In vivo<\/em>\u00a0PolyMag\u2122 <\/strong>Transfection Reagent\u00a0has been designed for\u00a0in vivo<\/em>\u00a0targeted transfection of various types of nucleic acids such as DNA, RNA, and oligonucleotides using magnetic nanoparticles coated with specific polymers. DNA complexes can be easily administrated through various injection routes such as systemic administration (intravenous, intra-artery) or local administration (intratumoral, intracerebroventricular).<\/p>\n\n\n\n

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See all in vivo<\/em> PolyMagTM<\/sup><\/a><\/div>\n<\/div>\n\n\n\n

For Infection:<\/h2>\n\n\n\n

In Vivo<\/em> ViroMag<\/h3>\n\n\n\n

In vivo<\/em>\u00a0ViroMag<\/strong>\u00a0Transfection Reagent\u00a0has been designed for\u00a0in vivo\u00a0targeted transduction with any viral vector. Virus\/nanoparticle complexes can be easily administrated through various injection routes such as systemic administration (intravenous, intra-artery) or local administration (intratumoral, intracerebroventricular).<\/p>\n\n\n\n

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See all in vivo<\/em> ViroMag<\/a><\/div>\n<\/div>\n\n\n\n

For Gene Silencing:<\/h2>\n\n\n\n

In Vivo<\/em> SilenceMagTM<\/sup><\/h3>\n\n\n\n

In vivo<\/em>\u00a0SilenceMag\u2122<\/strong>\u00a0is a rapid, simple and highly efficient method dedicated to transfecting small RNA (siRNA, miRNA) into target cells\/tissue\u00a0in vivo<\/em>. It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimises systemic distribution, increases gene-targeted inactivation and reduces toxicity. Furthermore, the magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue and thus improve the efficiency of silencing.<\/p>\n\n\n\n

This allows for decreasing the required process time of delivery to a few minutes which is crucial for the improvement of\u00a0in vivo<\/em>\u00a0small RNA delivery.\u00a0In vivo<\/em>\u00a0SilenceMag\u2122 is designed to meet\u00a0in vivo<\/em>\u00a0grade quality.<\/p>\n\n\n\n

In vivo<\/em> SilenceMag\u2122 benefits:<\/h4>\n\n\n\n