{"id":9915,"date":"2024-04-18T11:51:26","date_gmt":"2024-04-18T11:51:26","guid":{"rendered":"https:\/\/www.caltagmedsystems.co.uk\/information\/?p=9915"},"modified":"2024-04-18T11:51:26","modified_gmt":"2024-04-18T11:51:26","slug":"transduction-reagents-transduction-and-infection-enhancers","status":"publish","type":"post","link":"https:\/\/www.caltagmedsystems.co.uk\/information\/transduction-reagents-transduction-and-infection-enhancers\/","title":{"rendered":"Transduction Reagents: Transduction and Infection Enhancers"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">For All Viral Vectors:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">ViroMag<\/h3>\n\n\n\n<p><strong>ViroMag<\/strong>\u00a0Transduction Reagent\u00a0is a magnetic nanoparticle formulation dedicated to increasing virus infection and transduction capacities; it is suitable for all viruses. Based on the\u00a0Magnetofection\u2122\u00a0technology, this reagent allows concentrating the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus transduction with extremely low vector doses. Due to its specific properties,\u00a0ViroMag\u00a0is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency in promoting, controlling and assisting viral transductions so that no molecular biology processes or biochemical modifications are required.\u00a0<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-209.png\"><img loading=\"lazy\" decoding=\"async\" width=\"396\" height=\"577\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-209.png\" alt=\"\" class=\"wp-image-9916\" style=\"width:206px;height:auto\" srcset=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-209.png 396w, https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-209-206x300.png 206w\" sizes=\"auto, (max-width: 396px) 100vw, 396px\" \/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Increases transduction efficiency.<\/li>\n\n\n\n<li>Accelerates the transduction process.<\/li>\n\n\n\n<li>Efficient for hard-to-infect and non-permissive cells.<\/li>\n\n\n\n<li>Concentrates the viral dose onto the cells.<\/li>\n\n\n\n<li>Suitable for all types of viruses.<\/li>\n\n\n\n<li>Synchronise cell adsorption\/infection without modifications of the viruses.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=VM4\" style=\"color:#fbc100;background-color:#21318f\">See all ViroMag<\/a><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading clear\">Viro-MICST\u2122<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-210.png\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"478\" src=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-210.png\" alt=\"\" class=\"wp-image-9920\" style=\"width:258px;height:auto\" srcset=\"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-210.png 420w, https:\/\/www.caltagmedsystems.co.uk\/information\/wp-content\/uploads\/image-210-264x300.png 264w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/a><\/figure>\n\n\n\n<p><strong>Viro-MICST\u2122<\/strong>\u00a0Transduction\u00a0Reagent\u00a0allows genetically modifying cells directly on magnetic cell purification columns. Based on the\u00a0i-MICST\u2122\u00a0Technology (Integrated Magnetic Immuno-Cell Sorting and Transfection\/Transduction), this technology combines cell isolation and genetic modification in one simple and reliable integrated system. For efficient and selective gene delivery to target cells,\u00a0Viro-MICST\u2122\u00a0can be used in combination with any viral vector and allows you to reduce cell manipulation steps and save time and material.<\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Highly efficient.<\/li>\n\n\n\n<li>Rapid, simple and ready to use.<\/li>\n\n\n\n<li>Suitable for all cells.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=viro-micst\" style=\"color:#fbc100;background-color:#21318f\">See all Viro-MICST<sup>TM<\/sup><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading clear\">For Lenti &amp; Retro Virus:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">ViroMag RL<\/h3>\n\n\n\n<p><strong>ViroMag R\/L <\/strong>Transduction Reagent\u00a0is a magnetic nanoparticle formulation optimised for Retroviruses and Lentiviruses. Based on the\u00a0Magnetofection\u2122\u00a0technology, this reagent allows concentrating the complete applied dose of Retro\/Lentiviral particles onto cells within minutes, inducing a significant improvement of virus infectivity with extremely low vector doses. Due to its specific properties,\u00a0ViroMag R\/L\u00a0is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency in promoting, controlling and assisting viral transductions so that no molecular biology processes or biochemical modifications are required.<\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Increase transduction efficiency.<\/li>\n\n\n\n<li>Accelerate the transduction process.<\/li>\n\n\n\n<li>Efficient for hard-to-infect and non-permissive cells.<\/li>\n\n\n\n<li>Concentrate the viral dose onto the cells.<\/li>\n\n\n\n<li>Suitable for all types of Retro\/Lentivirus.<\/li>\n\n\n\n<li>Synchronise cell adsorption\/infection without modifications of the viruses.<\/li>\n<\/ul>\n\n\n\n<p>ViroMag RL\u00a0can also be used for Genome Edition using the CRISPR-Cas9 system. It is designed for the transfection of a viral particle solution composed of either one viral vector or vectors encoding cas9 and sgRNA.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=viromag%20r\" style=\"color:#fbc100;background-color:#21318f\">See all ViroMag RL<\/a><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">ViroMag Stem<\/h3>\n\n\n\n<p><strong>ViroMag Stem<\/strong>, a Magnetofection-based Lentiviral Transduction Enhancer, enables improved viral-driven genetic modification in a wide range of\u00a0stem cells\u00a0in different applications, such as ex vivo gene therapy and cell therapy.<\/p>\n\n\n\n<p>ViroMag Stem, as a stabilised magnetic nanoparticles formulation, offers a simple and reproducible method for increasing\u00a0lentiviral infection\u00a0and\u00a0transduction of difficult cell types\u00a0such as<strong>\u00a0<\/strong>CD34+ hematopoietic stem cells, both cell lines and primary cells,<strong>\u00a0<\/strong>in cell culture plate using the\u00a0Magnetofection<sup>TM<\/sup> technology.<\/p>\n\n\n\n<p>This method combines\u00a0maximum cell viability and high transduction efficiency,\u00a0while cell phenotype and differentiation potential are not affected.<\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Increase lentiviral transduction efficiency.<\/li>\n\n\n\n<li>Concentrate viral dose, promote and accelerate the transduction process.<\/li>\n\n\n\n<li>Efficient for hard-to-infect and non-permissive cells.<\/li>\n\n\n\n<li>Synchronise cell adsorption\/infection.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=viromag%20stem\" style=\"color:#fbc100;background-color:#21318f\">See all ViroMag Stem<\/a><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Viro-MICST\u2122 Stem<\/h3>\n\n\n\n<p><strong>Viro-MICST\u2122 Stem<\/strong> Transduction Enhancer is a new specific magnetic nanoparticle formulation issued from OZ Biosciences&#8217; Magnetofection\u2122 technology.<\/p>\n\n\n\n<p>Its properties were specifically designed for\u00a0Stem Cell lentiviral transduction\u00a0in order to achieve a high infection rate directly on\u00a0magnetic cell sorting devices\u00a0(column or magnet).<\/p>\n\n\n\n<p>As a stabilised magnetic nanoparticles formulation, Viro-MICST\u2122 Stem offers a simple and reproducible method for\u00a0increasing lentiviral infection and transduction\u00a0of difficult cell types such as CD34+ hematopoietic stem cells, both cell lines and primary cells,\u00a0during cell sorting.<\/p>\n\n\n\n<p>Due to the total biodegradability of the magnetic nanoparticles, Viro-MICST\u2122 Stem is non-toxic and\u00a0ideal for CD34+ Hematopoietic Stem Cell\u00a0transduction.<\/p>\n\n\n\n<p>This technology combines cell isolation and genetic modification in\u00a0one simple, efficient, and reliable integrated system. Viro-MICST\u2122 Stem Transduction\u00a0Reagent\u00a0allows genetically modifying cells directly on magnetic cell purification columns. Based on the\u00a0i-MICST\u2122\u00a0Technology (Integrated Magnetic Immuno-Cell Sorting and Transfection\/Transduction), this technology combines cell isolation and genetic modification in one simple and reliable integrated system.<\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Increased Lentiviral Infection.<\/li>\n\n\n\n<li>Reduce cell manipulation steps and save time and material.<\/li>\n\n\n\n<li>Designed for stem cells.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=viromicst%20stem\" style=\"color:#fbc100;background-color:#21318f\">See all Viro-MISCT<sup>TM<\/sup> Stem<\/a><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">LentiBlast Premium<\/h3>\n\n\n\n<p><strong>LentiBlast<\/strong>\u00a0<strong>Premium<\/strong>\u00a0is a novel\u00a0patented chemical composition that dramatically increases lentiviral infection and transduction efficiency in any type of cells, adherent or in suspension, primary or cell lines. The properties of this reagent allow simultaneously neutralising electrostatic repulsions between membrane and viral particles and enhancing viral fusion with the cell membrane. Due to a favourable \u201cmembrane permeable effect\u201d limiting the transmembrane potential changes,\u00a0LentiBlast\u00a0Premium\u00a0is non-toxic and compatible with cell viability.<\/p>\n\n\n\n<p>LentiBlast\u00a0Premium\u00a0Transduction Enhancer\u00a0overcomes obstacles that prevent successful transduction (cell density, passage number, lentivirus purity, MOI, &#8230;) and allows you to complete efficient transduction efficiencies without Polybrene.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">LentiBlast Premium Transduction Enhancer benefits:<\/h4>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li><strong>Increase lentivirus infection efficiency for hard-to-transduce cells<\/strong>: The right solution for Stem cells, Primary T cells.<\/li>\n\n\n\n<li><strong>Save effort &amp; money<\/strong>: Achieve the same transduction results with a lower viral titer.<\/li>\n\n\n\n<li><strong>Maximise Cell Viability<\/strong>: Non-toxic.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=LentiBlast\" style=\"color:#fbc100;background-color:#21318f\">See all LentiBlast Premium<\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">For Adenovirus:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">AdenoMag<\/h3>\n\n\n\n<p><strong>AdenoMag<\/strong>\u00a0Transfection Reagent\u00a0is a magnetic nanoparticle formulation specifically dedicated to enhancing Adenovirus and Adeno Associated Virus (AAV) infection and transduction capacities. Based on the\u00a0Magnetofection\u2122\u00a0technology, it allows concentrating the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus infectivity with extremely low vector doses. Due to its specific properties,\u00a0AdenoMag\u00a0is applicable to all adenoviral and AAV vectors and is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency for promoting, controlling and assisting Adenoviral and AAV transductions in a way that no molecular biology processes or biochemical modifications are required.\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li>Increase transduction efficiency.<\/li>\n\n\n\n<li>Accelerate the transduction process.<\/li>\n\n\n\n<li>Efficient for hard-to-infect and non-permissive cells.<\/li>\n\n\n\n<li>Concentrate the viral dose onto the cells.<\/li>\n\n\n\n<li>Synchronise cell adsorption\/infection without modifications of the viruses.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=adenomag\" style=\"color:#fbc100;background-color:#21318f\">See all AdenoMag<\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">For Adeno-associated Virus:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">AAVBlast<\/h3>\n\n\n\n<p><strong>AAVBlast<\/strong>\u00a0is a chemical AAV transduction enhancer, very effective in promoting viral-mediated genetic modification.\u00a0AAVBlast\u00a0improves transduction in a wide range of cell types from classic cell lines to primary cells or mesenchymal stem cells. Its patented formulation and unique thermoresponsive gelling properties, ensure the protection of viral particles and allow an increase in transduction efficiency. Non-toxic, the new\u00a0AAVBlast\u00a0AAV transduction enhancer is also compatible with in vivo experiments.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Effective\u00a0in a\u00a0wide range of cell types: cell lines, primary cells, mesenchymal Stem Cells.<\/li>\n\n\n\n<li>Compatible\u00a0with\u00a0various serotypes.<\/li>\n\n\n\n<li>Thermoresponsive\u00a0gelling properties: protection of viral particles.<\/li>\n\n\n\n<li>Non-toxic.<\/li>\n\n\n\n<li>Compatible\u00a0with\u00a0in-vivo\u00a0experiments.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">AAVBlast Transduction Enhancer benefits:<\/h4>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:16px\">\n<li><strong>Increase AAV infection efficiency for hard-to-transduce cells<\/strong>: The right solution for Stem cells, Primary T cells.<\/li>\n\n\n\n<li><strong>Save effort &amp; money<\/strong>: Achieve the same transduction results with a lower viral titer.<\/li>\n\n\n\n<li><strong>Maximize Cell Viability<\/strong>: Non-toxic.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/www.caltagmedsystems.co.uk\/pricing_ordering\/index.php?group_1=All&amp;group_2=All&amp;supplier=76&amp;clonality=All&amp;host=All&amp;species=All&amp;applications=All&amp;regulatory_status=All&amp;searchwords=AAVBlast\" style=\"color:#fbc100;background-color:#21318f\">See all AAVBlast<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"clear\"> <\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background\" style=\"background-color:#21318f;color:#21318f\"\/>\n\n\n\n<p>Information provided by&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/ozbiosciences\/\">OZ Biosciences<\/a>.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.caltagmedsystems.co.uk\/\">Caltag Medsystems&nbsp;<\/a>is the distributor of&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/ozbiosciences\/\">OZ Biosciences<\/a>&nbsp;products in the UK and Ireland. If you have any questions about these products, please&nbsp;<a href=\"https:\/\/www.caltagmedsystems.co.uk\/contact.php\">contact us<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>OZ Biosciences\u2019 transduction and infection enhancers are available for all viral vectors, Lenti &#038; Retro Virus, Adenovirus and stem cells. <\/p>\n","protected":false},"author":13,"featured_media":9928,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,787],"tags":[542,869,868],"class_list":["post-9915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-information","category-transduction","tag-oz-biosciences","tag-transduction-and-infection-enhancers","tag-transduction-reagents"],"_links":{"self":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/9915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/comments?post=9915"}],"version-history":[{"count":11,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/9915\/revisions"}],"predecessor-version":[{"id":9929,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/posts\/9915\/revisions\/9929"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media\/9928"}],"wp:attachment":[{"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/media?parent=9915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/categories?post=9915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.caltagmedsystems.co.uk\/information\/wp-json\/wp\/v2\/tags?post=9915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}