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Cell Culture - Mar 2019

3D Tumor Modeling with Next-Generation NanoCulture Plates

Scaffolding is important for 3D cell culture to mimic tissue micro environment. However, working with the traditional gel format is a cumbersome procedure for many assay types including high throughput screening.
 
MBL International is excited to announce the launch of Next-Generation NanoCulture Plates for 3D tumor cell culturing. The NanoCulture Plate/Dish (NCP) is engineered with an evenly patterned nano-scale structure on a proprietary plastic film attached to the bottom of the plate. The pattern mimics the extracellular matrix and allows for cells to migrate across the plate and form healthy spheroids.
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Newsletter - Mar 2019

Cells & Tissues: Frozen Skin Inventory, Dermal Cell System, Fully Traceable Cell Culture Media, Animal Cells, Brain Teasers and More

1. Frozen Skin Inventory
2. Researching the Dermal Cell System?
3. Psoriasis Research Products
4. Researching Acute Myeloid Leukemia (AML)? 
5. The Importance of Fully Traceable Cell Culture Media
6. Animal Cells
7. Clinically Relevant Mesenchymal Stem Cell Populations for                  Research
8. Brain Teaser: What do you see?

Frozen Skin Inventory 
 
Biopredic International is a major worldwide supplier of human and animal skin products. These can be used for applications including compound penetration, skin irritation studies, toxicology, metabolism and primary cell isolation. The inventory currently contains abdominal and breast skin available as full thickness or dermatomed pieces Request the latest inventory
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Adipogen - Mar 2019

Inflammasome and Inflammation Research

Caltag Medsystems would like to share with you our key inflammasome and inflammatory research tools. Inflammasomes are multi-protein complexes implicated in physiological and pathological inflammation, and their activity has been linked to the induction of numerous inflammatory responses, either harmful or beneficial to the organism. Both inflammasomes and inflammation play a vital role in immunity.

View our Inflammasome brochure and poster for more information, or contact us to request your complimentary copy.
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Metabolism - Mar 2019

Uptake Assay Kits: measuring Nature’s rates of life

The measurement and quantitation of metabolite uptake processes, such as glucose or fatty acids is crucial in establishing the initiation of cancer and diabetes respectively. Therefore, high-throughput uptake assays offer outstanding advantages in order to compare multiple cell lines, treatment and/or microenvironmental conditions. BioVision offers a comprehensive series of Uptake Assay Kits measuring glucose, fatty acid or HDL uptake in cultured cells in real-time. Our assays are non-radioactive, highly sensitive, reproducible, and HTS adaptable for screening of these molecule uptake-modulating test/treatment conditions.
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Cell Culture - Mar 2019

Renal System Product Highlights

Caltag Medsystems offer a range of renal cells, tissue, DNA and RNA, isolated from human, mouse and rat for your research studies. In addition to renal biological samples, we also offer a wide range of assay kits, antibodies, and recombinant proteins for key kidney disease biomarkers, such as NGAL, KIM-1, L-FABP and IL-18.

If you can’t find the product that you are looking for, please contact us. We offer a product sourcing capability and a tissue procurement service.

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ELISA - Mar 2019

Reduce Pipetting Mistakes with EASYview ELISAs

The Diaclone ELISA kits now contain the EASYview coloured reagents! Designed as a visual aid to facilitate the pipetting and filling of Diaclone ELISA plates, EASYview:
Improves well visualisation
Helps to avoid pipetting mistakes
Has no impact on assay performance
Significant validation has been performed to ensure that there is no impact on assay performance and the excellence of the results obtained with the Diaclone ELISA kits. Learn More...
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Newsletter - Feb 2019

Drug Discovery Solutions: CTC Isolation Devices, Hepatic Cell Line, Stabilise Circulating Tumour Cells, Cell Expansion Service and More

Welcome to the Caltag Medsystems Drug Discovery Product Highlights. Be sure to check out our brainteaser at the end of the newsletter. 
 
1.Gain Greater Control of your Cell Research with StemBioSys
2.Silensomes: Quantifying the Contribution of CYP Enzymes in Drug Metabolism
3.HepaRG: Hepatic Cell line
4.Liquid Biopsy: CTC Isolation Devices
5.Alzheimers, Multiple Sclerosis, Depression, Schizophrenia and more
6.Stabilise Circulating Tumour Cells with TransFix for High-Resolution Image Flow Cytometry
7.Cell Expansion Service
8.Do you Require Human Tissue Samples for Research?
9.Brain Teaser: Four Sisters

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Metabolism - Feb 2019

Metabolism Research - Assays, Antibodies and More


Caltag Medsystems offer 1000s of products for research into many metabolic pathways, such as:

Carbohydrate and Sugar Metabolism
Drug Metabolism
Lipid and Fatty Acid Metabolism
Steroid Metabolism
Protein and Amino Acid Metabolism
And more

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Cell Culture - Feb 2019

Dermal Cell System Research Products

The dermal cell system protects the body’s tissues and organs from dehydration, infectious organisms, and rapid temperature changes. Caltag Medsystems work with various suppliers to assist with your research in this area. We provide access to a variety of cells including: 

Melanocytes
Keratinocytes
Endothelial Cells
Fibroblasts

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Cell Culture - Feb 2019

A Deeper Look Into Stem Cell Differentiation By qPCR Array

Example applications:
 
Basic research: 
Identify cell signaling aberrancies
Determine relevancy of biological pathways
Study gene expression manipulation
Examine mechanisms that may characterize phenotypes
Compare cell functionality and biology in various conditions
Confirm clustered RNA-Seq, microarrays and other preliminary data

Translational research 
Evaluate novel target genes or markers in discovery biology
Determine drug mechanism of action in drug screening
Evaluate new drug performance and enhance development
Research drug metabolism

Clinical research 
Predict drug efficacy for individual patients
Assess effects of combination therapy
Evaluate drug safety and compatibility


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Tetramers, Flow Cytometry - Feb 2019

Monitoring of Immune Response to Influenza Infection

Influenza, often referred to as “the flu”, is one of the most common respiratory infections in humans1. Influenza rapidly spreads around the world in seasonal epidemics and imposes a considerable economic burden in the form of health care and hospitalization costs.
 
Influenza viruses are grouped into 3 major types (A, B, and C), and strains are further divided into multiple subtypes based on the virus surface proteins hemagglutinin and neuraminidase. Investigating immune responses to influenza virus infection among the different subtypes is important for the development of more effective influenza vaccines.
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Newsletter - Jan 2019

Life Science Solutions: Autophagy, Human Tissue Samples, ELISA Kits, Antibodies, Endothelial cells and More

Autophagy Research Poster – Claim Yours Today 
 
Autophagy is associated with neurodegenerative diseases, infection, cardiac disease, cancer and aging. MBL International have a range of tools to research autophagy, including: Keima-Red fluorescent protein for detection of mitophagy in living cells, LC3/Atg8 antibodies, p62 ELISA Kits and Antibodies, and antibodies against many other autophagy markers. Contact us to learn more, or to request your free Autophagy poster.
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ELISA - Jan 2019

There’s An Easier Way To Measure Vancomycin

BioVision’s ELISA Kit for Vancomycin 
 
Vancomycin is one of prescribed classes of glycopeptide antibiotics used to treat various bacterial infections including complicated skin, bone and bloodstream infections. Despite its strong efficacy, side-effects, toxicity and antibiotic resistance remain an issue that require close monitoring. Compared to traditional techniques/instruments (HPLC or GC-MS) which are expensive, and time-consuming, BioVision offers a simple and cost-effective method to detect and quantify Vancomycin (E4605) in various samples with consistent results.
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Adipogen - Jan 2019

TOPIX - Obesity & Diabetes Related Biologicals and Small Molecules

Obesity & Diabetes Reagents
Detection of Asprosin
Unique RBP4 ELISA Kit
FABP4 & Potent FABP4 Inhibitor
Small Molecules for Obesity & Diabetes Research 
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Transfection - Jan 2019

Neuroscience - Find the Right Transfection Solution

Discover NeuroMag 

Successfully Tested and Published!
 
Transfected Cells: Hippocampal, Cortical, Motor Neurons, Dopaminergic, Glioblastoma, Neuroblastoma, DRG, Neural Stem Cells, Oligodendrocytes....
 
Glial-Mag
 
New Product - Ideal for transfection of microgial cells such as BV2, N9, N13...
 
Glial-Mag reagent is a specific magnetic nanoparticles formulation issued from our Magnetofection technology that enhances transfection efficicency.
 


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Immunology - Jan 2019

Psoriasis Research

Caltag Medsystems provide a range Interleukin 17 (IL-17) research reagents. IL-17 is a pro-inflammatory cytokine produced by T helper 17 cells, activation of which is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis.
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Cell Culture - Jan 2019

Clinically Relevant Mesenchymal Stem Cell Populations for Research

Renovos offer unique Bone Marrow Mesenchymal Stem Cells (MSCs), which have been isolated from patients with Osteoarthritis. Renovos provide heterogeneous populations of MSCs for biologics and biomaterial testing.
 
By applying clonal culture techniques, Renovos MSCs are supplied at the highest purity and at an early passage, allowing for cell expansion. 
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Cytomark - Jan 2019

New Research demonstrates the benefits of TransFix®/EDTA Vacuum Blood Collection Tubes

A new paper has been published in Cytometry part B, comparing two blood stabilising products: the TransFix®/EDTA Vacuum Blood Collection Tube (TVT), and the Streck Cyto-Chex BCT.

Both devices are intended for collection and storage of whole blood specimens for immunophenotyping of leukocytes by flow cytometry for up to 14 days. However, the authors found...

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Cell Culture - Jan 2019

Multiple Sources of Mesenchymal Stem Cells, Matrices and Media

Did you know that Caltag Medsystems can provide mesechymal stem cells (MSC’s) from a variety of sources?
 
MSC’s are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells).

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Flow Cytometry - Jan 2019

Multiple Myeloma – Product Highlights

Looking into Multiple Myeloma? 
 
Caltag Medsystems works with various suppliers to provide numerous products for multiple myeloma research, diagnosis and monitoring, including:
 
Cell and Tissues from patients with Multiple Myeloma
Whole Blood
Plasma
Serum
Cells and Cell Lines
Mononuclear cells from peripheral blood and bone marrow (PBMC or BMNC)
CD38 & CD138 IVD/CE and RUO Antibodies – Multiple Myeloma cases show High expression levels in CD38 and low in CD138

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Cell Culture - Jan 2019

New: Measure Angiogenesis in Real Time using GFP Labelled HUVECs

The GFP V2a Kit™ - Vasculogenesis to Angiogenesis, is a validated, in vitro, human primary cell co-culture model of angiogenesis that allows the dynamic measurement of all phases of the angiogenic process.
 
Tubules formed contain a lumen and resemble the morphology and range of capillary lengths found in microvascular beds in vivo.

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Newsletter - Jan 2019

Cells & Tissues: Frozen Haematopoietic Cells, Cell Expansion Service, Tissue Procurement, Transfection Reagents, Brain Teasers and More

Next Day Delivery of Frozen Haematopoietic Cells 
 
Caltag Medsystems has been awarded a Human Tissue Authority (HTA) license. This allows us to store human tissue in our liquid nitrogen tanks in-house in the United Kingdom. We now have several types of haematopoietic cells (from bone marrow and peripheral blood) in stock available for next day delivery. Contact us to learn more about our available stock or if you require any other cell types or tissues to be stored in the UK, for convenient, rapid delivery.
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Cell Culture, Blood - Jan 2019

Cell & Immunotherapy: High Quality Starting Material Available

Caltag Medsystems has agreements in place with several suppliers of high quality apheresis material. All our suppliers follow a strict ethical framework with donor consent and ethical board approval of all collection protocols. 
  
With projects in cell and gene therapy development, it is critical to use a supplier with access to high quality material and attentive customer service. At Caltag Medsystems, each of our customers works with a product manager to ensure that their exact requirements are understood and met. We liase directly with our suppliers to find our customers the best material at competitive prices. With our 24 hour response time to our customers and ability to coordinate the logistics of shipping fresh blood products to our customers in Europe, Caltag Medsystems takes pride in our customer satisfaction.
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Antibiotics - Jan 2019

eTOPIX Functional and Recombinant Antibodies

New & Unique
Functional and Recombinant Antibodies
Immune Checkpoint Proteins
Conformation-specific Antibodies 

NEW Mouse-specific anti-PD-1 Blocking Antibody
  
PD-1 (mouse), mAb (blocking) (1H10)
AG-20B-0075
PD-1 (mouse), mAb (blocking) (1H10) (PF)
AG-20B-0075PF
  
CD279 (PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 & ICOS) or downregulate T cell activation (CTLA-4 & PD-1).


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Immunology - Jan 2019

TIM Recombinant Proteins

Recombinant TIM Proteins from BioVision 
 
Proteins of the transmembrane immunoglobulin and mucin domain (TIM) family are expressed by multiple cell types within the immune system. They are important regulators of immunity and play prominent roles in the control of auto-reactive immune responses. Studies over the last several years have suggested that these proteins may be promising targets for therapeutic manipulation of immune responses. Thus, modulation of TIM protein function may prove to be a useful strategy to control autoimmune diseases and has opened up the possibility of a new area for immune modulation. BioVision offers an extensive collection of recombinant TIM family proteins that can serve as useful tools to support this research.
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