20S Immunoproteasome (mouse) (untagged)
| Code | Size | Price |
|---|
| SBB-PP0083-C050 | 50 ug | £349.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Shipping:
Dry Ice
Storage:
-80°C
Further Information
Concentration:
Lot dependent.
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Protein. Mouse 20S Immunoproteasome. Source: Mouse Spleen. Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >92% (SDS-PAGE). The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two internal 7-subunit containing rings each possessing 3 specific subunits responsible for proteasome catalytic activity. In immunoproteasomes these subunits (beta1, beta2, beta5) are replaced by three inducible subunits: PSMB9, PSMB10 and PSMB8, (beta1i, beta2i, beta5i). These stress-induced subunits allow for the production of MHC-1 associating peptides, which are displayed as antigens on the cell surface. These displayed peptides can then be recognized by immune surveillance CD8 T cells. 20S immunoproteasome is recognized as a strong drug target for autoimmune disease and cancer.
Molecular Weight:
~700kDa
Package Type:
Plastic Vial
Product Description:
The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two internal 7-subunit containing rings each possessing 3 specific subunits responsible for proteasome catalytic activity. In immunoproteasomes these subunits (?1, ?2, ?5) are replaced by three inducible subunits: PSMB9, PSMB10 and PSMB8, (?1i, ?2i, ?5i). These stress-induced subunits allow for the production of MHC-1 associating peptides, which are displayed as antigens on the cell surface. These displayed peptides can then be recognized by immune surveillance CD8 T cells. 20S immunoproteasome is recognized as a strong drug target for autoimmune disease and cancer.
Purity:
>92% (SDS-PAGE)
Sequence:
Mouse 20S Immunoproteasome.
Source / Host:
Mouse Spleen
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.