anti-ACE2 (human) mAb (AC18F) (Biotin)
| Code | Size | Price |
|---|
| AG-20A-0032B-C050 | 50 ug | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1κ
Antibody Clonality: Monoclonal
Antibody Clone: AC18F
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Flow Cytometry
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
SARS Receptor; Angiotensin-converting Enzyme 2; ACEH; Metalloprotease MPROT15; SARS-CoV-2 Receptor
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human ACE2.
Labels - Conjugates:
Biotin
Long Description:
Monoclonal Antibody. Recognizes human ACE2. Isotype: Mouse IgG1kappa. Clone: AC18F. Applications: ELISA, FACS, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.
NCBI, Uniprot Number:
Q9BYF1
Package Type:
Plastic Vial
Product Description:
Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Specificity:
Recognizes human ACE2. Does not detect recombinant human ACE2 that has a tag at the C-terminus of the protein.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34 positive cells in rabbit atherosclerotic plaques: A. Zulli, et al.; Exp. Physiol. 93, 564 (2008) | Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications: VB. Patel, et al.; Clin. Sci. 126, 471 (2014) | Syncytia formation by SARS-CoV-2-infected cells: J. Buchrieser, et al.; EMBO J. e106267 (2020) | High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients: X. Song,et al.; bioRxiv (Preprint) (2020) | Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia: S. Kreutmair, et al.; Immunity 54, 1578 (2021)