anti-AIM2 (human) mAb (3B10)
| Code | Size | Price |
|---|
| AG-20B-0040-C100 | 100 ug | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 3B10
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunocytochemistry (ICC)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
Interferon-inducible Protein AIM2; Absent in Melanoma 2
Concentration:
1 mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Human AIM2 (aa 1-186).
Long Description:
Monoclonal Antibody. Recognizes human AIM2. Isotype: Mouse IgG1. Clone: 3B10. Applications: ICC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.
NCBI, Uniprot Number:
O14862
Package Type:
Plastic Vial
Product Description:
AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes human AIM2.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Expression of IFI 16 in epithelial cells and lymphoid tissues: W. Wei, et al.; Histochem. Cell Biol. 119, 45 (2003) | Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005) | AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009) | AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009) | A novel flow cytometric method to assess inflammasome formation: D.P. Sester, et al.; J. Immunol. 194, 455 (2015) | Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection: C. Sun, et al.; J. Immunol. 194, 1819 (2015) | Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication: Y. Maruzuru, et al.; Cell Host Microbe. 23, 254 (2018) | PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells: D. Massa, et al.; J. Biol. Chem. 295, 4438 (2020)