anti-Giantin mAb (rec.) (TA10) (ATTO 488)

Golgin Subfamily B Member 1; 372 kDa Golgi Complex-associated Protein; GCP372; Macrogolgin

1mg/ml

32160000

liquid

Liquid. In PBS containing 0.02% sodium azide.

Human recombinant giantin.

ATTO 488

Recombinant Antibody. Recognizes human and mouse giantin. Species cross-reactivity: Human, Mouse. Clone: TA10. Isotype: Human IgG2lambda. Applications: ICC. Host: Purified from HEK 293 cell culture supernatant. Liquid. In PBS containing 0.02% sodium azide. Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. It is also an antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

Q14789

anti-Giantin, monoclonal antibody (recombinant) (TA10) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain. anti-Giantin, monoclonal antibody (recombinant) (TA10) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

Plastic Vial

Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. It is also an antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

>95% (SDS-PAGE)

Produced without the use of animals. Purified from HEK 293 cell culture supernatant.

Recognizes human and mouse giantin.

Non-hazardous

Primary Antibody Conjugates

12352203

Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.