1-Azakenpaullone
| Code | Size | Price |
|---|
| AG-CR1-0035-M001 | 1 mg | £80.00 |
Quantity:
| AG-CR1-0035-M005 | 5 mg | £220.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
Appearance:
Off-white to tan solid.
CAS:
676596-65-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChiKey:
NTSBZVCEIVPKBJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 676596-65-9. Formula: C15H10BrN3O. MW: 328.2. Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM).
MDL:
MFCD09037522
Molecular Formula:
C15H10BrN3O
Molecular Weight:
328.2
Other data:
Stock solutions are stable for up to 6 months when stored at -20°C.
Package Type:
Vial
Product Description:
Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM) [1, 2].
Purity:
>98% (HPLC, NMR)
SMILES:
BrC1=CC2=C(NC3=C2CC(=O)NC2=C3N=CC=C2)C=C1
Solubility Chemicals:
Soluble in DMSO; insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett.14, 413 (2004) | Studying the mechanism that enables paullones to selectively inhibit glycogen synthase kinase 3 rather than cyclin-dependent kinase 5 by molecular dynamics simulations and free-energy calculations: Q. Chen, et al.; J. Mol. Model. 17, 795 (2011)
Related Products
| Product Name | Product Code | Supplier | Alsterpaullone | AG-CR1-0036 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|