Q-VE-OPh (Negative Control for Q-VD-OPh)

AdipoGen Life Sciences
Product Code: AG-CP3-0007

CodeSizePrice
AG-CP3-0007-M0011 mg£145.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Blue Ice
Storage:
-20°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
Q-Val-Glu-OPh; pan-Caspase Inhibitor (Negative Control); N-(2-Quinolyl)-L-valyl-L-glutamyl-(2,6-difluorophenoxy) methylketone
Appearance:
White solid.
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C27H27F2N3O6/c1-15(2)24(32-26(36)21-11-10-16-6-3-4-9-19(16)30-21)27(37)31-20(12-13-23(34)35)22(33)14-38-25-17(28)7-5-8-18(25)29/h3-11,15,20,24H,12-14H2,1-2H3,(H,31,37)(H,32,36)(H,34,35)/t20?,24-/m0/s1
InChiKey:
AXCYQCBDFVOWSL-JWIMYKKASA-N
Long Description:
Chemical. Formula: C27H27F2N3O6. MW: 527.5. Synthetic. Cell permeable, non-toxic negative control for the caspase inhibitor Q-VD-OPh (Prod. No. AG-CP3-0006). Stable in aqueous environment. Several folds less inhibitory activity than Q-VD-OPh. Perfect for both in vitro and in vivo studies.
MDL:
N/A
Molecular Formula:
C27H27F2N3O6
Molecular Weight:
527.5
Package Type:
Vial
Product Description:
Cell permeable, non-toxic negative control for the caspase inhibitor Q-VD-OPh (Prod. No. AG-CP3-0006). Stable in aqueous environment. Several folds less inhibitory activity than Q-VD-OPh. Perfect for both in vitro and in vivo studies.
Purity:
>95% (TLC)
SMILES:
CC(C)[C@H](NC(=O)C1=CC=C2C=CC=CC2=N1)C(=O)NC(CCC(O)=O)C(=O)COC1=C(F)C=CC=C1F
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.

References

Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003) | The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15, 1403 (2010) | Q-VE-OPh, a Negative Control for O-Phenoxy-Conjugated Caspase Inhibitors: B. Southerland, et al.; J. Cell Death 3, 33 (2010) | The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36, 884 (2012)