Z-VRPR-FMK
| Code | Size | Price |
|---|
| AG-CP3-0008-C500 | 500 ug | £250.00 |
Quantity:
| AG-CP3-0008-M001 | 1 mg | £440.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Z-Val-Arg-Pro-DL-Arg-FMK . TFA; MALT1 Inhibitor
Appearance:
White to slightly yellow solid.
CAS:
1381885-28-4 (free base)
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.Hygroscopic.Protect from moisture.
InChi:
InChI=1S/C31H49FN10O6/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38)/t21?,22-,23-,25-/m0/s1
InChiKey:
DYQKGOBRZWMAHV-YTJMMMLMSA-N
Long Description:
Chemical. CAS: 1381885-28-4 (free base). Formula: C31H49FN10O6 . C2HF3O2. MW: 676.8 . 114.0. Synthetic. Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
MDL:
MFCD32200345
Molecular Formula:
C31H49FN10O6 . C2HF3O2
Molecular Weight:
676.8 . 114.0
Package Type:
Vial
Product Description:
Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
Purity:
>90% (HPLC)
Sequence:
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
SMILES:
OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF
Solubility Chemicals:
Soluble in water (1mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.
References
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008) | Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma: S. Hailfinger, et al.; PNAS 106,19947 (2009) | Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2: S.I. Gringhuis, et al.; PLoS Pathogens 7, e1001259 (2011) | Crystal structure of a Trypanosoma brucei metacaspase: K. McLuskey, et al.; PNAS 109, 7469 (2012) | MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012) | The protease activity of the paracaspase MALT1 is controlled by monoubiquitination: C. Pelzer, et al.; J. Immunol. 14, 337 (2012)
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