GV-58

AdipoGen Life Sciences
Product Code: AG-MR-C0035

CodeSizePrice
AG-MR-C0035-M0011 mg£75.00
Quantity:
AG-MR-C0035-M0055 mg£225.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
(2R)-2-[(6-{[(5-Methylthiophen-2-yl)methyl]amino}-9-propyl-9H-purin-2-yl)amino]butan-1-ol; Rx-ID: 23159892
Appearance:
White to off-white solid.
CAS:
1402821-41-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H319
InChi:
InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1
InChiKey:
DPTXJOUVBMUSGY-CYBMUJFWSA-N
Long Description:
Chemical. Formula: C18H26N6OS. MW: 374.5. Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.
Molecular Formula:
C18H26N6OS
Molecular Weight:
374.5
Package Type:
Vial
Precautions:
P280, P305, P351, P338
Product Description:
Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.
Purity:
>97% (NMR)
Signal word:
Warning
SMILES:
CCCN1C=NC2=C(NCC3=CC=C(C)S3)N=C(N[C@H](CC)CO)N=C12
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Synthesis and biological evaluation of a selective N- and P/Q-type Calcium channel agonist: M. Liang, et al.; ACS Med. Chem. Lett. 3, 985 (2012) | New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases: T.B. Tarr, et al.; Ann. N. Y. Acad. Sci. 1275, 85 (2012) | Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome: T.B. Tarr, et al.; J. Neurosci. 33, 10559 (2013) | Complete reversal of Lambert?Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist: T.B. Tarr, et al.; J. Physiol. 3687, 592 (2014) | Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome: T.B. Tarr, et al.; Mol. Neurobiol. 52, 456 (2015) | The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS: A. Tedeschi, et al.; Neuron 92, 419 (2016)

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