anti-IL-1alpha (p18) (mouse) mAb (Teo-1)

Interleukin-1alpha IL-1alpha

1mg/ml

32160000

liquid

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Recombinant mouse mature IL-1alpha.

Monoclonal Antibody. Recognizes mouse IL-1alpha p18 cleaved and full-length fragments. Isotype: Mouse IgG. Clone: Teo-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

P01582

Plastic Vial

The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

>95% (SDS-PAGE)

Purified from concentrated hybridoma tissue culture supernatant.

Recognizes mouse IL-1alpha p18 cleaved and full-length fragments.

Non-hazardous

Primary Antibodies

12352203

Stable for at least 1 year after receipt when stored at -20°C.