GPX3 (human) ELISA Kit (Twin Plex)
| Code | Size | Price |
|---|
| AG-45A-0020YEK-KI01 | 96 wells | £550.00 |
Quantity:
| AG-45A-0020YTP-KI01 | 2 x 96 wells | £980.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
+4°C
Further Information
Alternate Names/Synonyms:
Glutathione Peroxidase 3
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Form (Short):
liquid
Handling Advice:
After standard reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Plate and reagents should reach room temperature before use.
Long Description:
ELISA Assay. Detects human GPX3. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.5 to 32ng/ml. Sensitivity: 100pg/ml. Glutathione peroxidase 3 (GPX3; GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.
NCBI, Uniprot Number:
P22352
Package Type:
Box
Product Description:
Glutathione peroxidase 3 (GPX3; GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.
Range:
0.5 to 32ng/ml
Sample Type:
Cell Culture Supernatant, Plasma, Serum
Sensitivity:
100pg/ml
Specificity:
Detects human GPX3.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
12 months after the day of manufacturing. See expiry date on ELISA Kit box.
References
Dysregulation of Adipose Glutathione Peroxidase 3 in Obesity Contributes to Local and Systemic Oxidative Stress: Y.S. Lee, et al.; Mol. Endocrinol. 22, 2176 (2008) | Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells: S.S. Chung, et al.; Mol. Cell Biol. 29, 20 (2009) | Oxidative stress after antenatal betamethasone: Acute downregulation of glutathione peroxidase-3: J. Verhaeghe, et al.; Early Hum. Dev. 85, 767 (2009) | Oxidant balance markers at birth in relation to glycemicand acid-base parameters: J. Verhaeghe, et al.; Metabolism 60, 71 (2011) | Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation: R. Lobb; University Waikato (Thesis) (2011) [http://hdl.handle.net/10289/5709] | Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression: D. Agnani, et al.; J. Ovarian Res. 4, 18 (2011) | Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014) | Role of GPx3 in PPARgamma-induced protection against COPD-associated oxidative stress: A.T. Reddy, et al.; Free Rad. Biol. Med. 126, 350 (2018) | Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis: W-J. Lee, et al.; Clin. Chim. Acta 489, 177 (2019) | Pathological myopia-induced antioxidative proteins in the vitreous humor: Q. Wei, et al.; Ann. Transl. Med. 8, 193 (2020) | Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study: M. Tomandlova, et al.; Free Radic. Biol. Med. 174, 66 (2021)
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