NMNAT2 (human) (rec.) (His)
| Code | Size | Price |
|---|
| AG-40A-0153T-C010 | 10 ug | £140.00 |
Quantity:
| AG-40A-0153T-3010 | 3 x 10 ug | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Nicotinamide Mononucleotide Adenylyltransferase 2; NMN Adenylyltransferase 2; NaMN Adenylyltransferase 2
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl plus 0.025% CHAPS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. Human NMNA2 (aa 2-307) is fused at the N-terminus to a His-tag. Source: E. coli. Lyophilized in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl plus 0.025% CHAPS. Purity: >90% (SDS-PAGE). Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration (axon degeneration induced by nerve injury), whereas NMNAT overexpression rescues axons from degeneration.
Molecular Weight:
~35kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9BZQ4
Package Type:
Plastic Vial
Product Description:
Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration (axon degeneration induced by nerve injury), whereas NMNAT overexpression rescues axons from degeneration.
Purity:
>90% (SDS-PAGE)
Sequence:
Human NMNA2 (aa 2-307) is fused at the N-terminus to a His-tag.
Source / Host:
E. coli
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.