Cyclosporin D
Product Code: AG-CN2-0445
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0445-M001 | 1 mg | £85.00 |
Quantity:
| AG-CN2-0445-M005 | 5 mg | £220.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Val2-Cyclosporine; CsD
Appearance:
White solid.
CAS:
63775-96-2
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS08
Handling Advice:
Keep cool and dry.Protect from light.
Hazards:
H302, H350, H360
InChi:
InChI=1S/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26-/t41-,42+,43-,44+,45+,46+,47+,49-,50+,51+,52+,53-/m1/s1
InChiKey:
ZNVBEWJRWHNZMK-AHWIEGLVSA-N
Long Description:
Chemical. CAS: 63775-96-2. Formula: C63H113N11O12. MW: 1216.7. Isolated from Fusarium solani. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Moderate inhibitor of formyl peptide-induced superoxide formation.
MDL:
MFCD11111526
Molecular Formula:
C63H113N11O12
Molecular Weight:
1216.7
Package Type:
Vial
Precautions:
P301, P312, P308, P313, P330
Product Description:
Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Moderate inhibitor of formyl peptide-induced superoxide formation.
Purity:
>97% (HPLC)
Signal word:
Danger
SMILES:
[H][C@@]1([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(NC1=O)C(C)C)C(C)C
Solubility Chemicals:
Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
Source / Host:
Isolated from Fusarium solani.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.
References
Effect of column temperature and eluent flow rate on the high performance liquid chromatographic analysis of cyclosporin a and d: K.A. Mereish & C.T. Ueda; Pharm. Res. 1, 245 (1984) | The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988) | Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wentzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)
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