EGF receptor Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-516-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-516-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized EGF receptor recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted EGF receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any
Documents
Further Information
Additional Names:
ERBB, HER1, mENA, ERBB1, PIG61, ERBB, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1
Background:
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGF, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.
Biological Activity:
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
1956
NCBI Official Name:
epidermal growth factor receptor
NCBI Official Symbol:
EGFR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_005219.2
Protein GI Number:
29725609
Purity:
Greater than or equal to 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
P00533