IL-13 Variant Recombinant Protein

ProSci
Product Code: PSI-40-259
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-259-0.002mg0.002mg£300.00
Quantity:
PSI-40-259-0.01mg0.01mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized IL-13 Variant recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-13 Variant is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with an

Documents

Further Information

Additional Names:
P600, IL-13, NC30, Interleukin-13
Background:
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. This genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
Biological Activity:
This IL - 13 analog shows a two fold increase, relative to wild type IL - 13, in bioactivity as measured by the in - vitro dose dependent activation of STAT6 and IL - 13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL - 13, as measured by the induction of airway hyper - responsiveness.
NCBI Gene ID #:
3596
NCBI Official Name:
interleukin 13
NCBI Official Symbol:
IL13
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002179.2
Protein GI Number:
26787978
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P35225