Thrombopoietin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-285-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-285-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Thrombopoietin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Thrombopoietin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with
Documents
Further Information
Additional Names:
ML, TPO, MGDF, MKCSF, MPLLG, THCYT1, Thrombopoietin, C-mpl ligand, ML
Background:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Biological Activity:
The ED50 was determined by the dose - dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.
NCBI Gene ID #:
7066
NCBI Official Name:
thrombopoietin
NCBI Official Symbol:
THPO
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000451.1
Protein GI Number:
4507493
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P40225