4-1BB Receptor Recombinant Protein

ProSci
Product Code: PSI-40-307
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-307-0.005mg0.005mg£300.00
Quantity:
PSI-40-307-0.02mg0.02mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized 4-1BB Receptor recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted 4-1BB Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with

Documents

Further Information

Additional Names:
ILA, 4-1BB, CD137, CDw137, ILA, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor
Background:
4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.
Biological Activity:
Biological activity was determined by its inhibitory effect of the 4 - 1BBL mediated stimulation of IL - 8 production by human PBMC. About 90% of inibition was seen using a concentration of 1μg for both 4 - 1BBL and 4 - 1BBR.
NCBI Gene ID #:
3604
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol:
TNFRSF9
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001552.2
Protein GI Number:
5730095
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q07011