Soluble Fas Receptor Recombinant Protein

ProSci
Product Code: PSI-40-311
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-311-0.005mg0.005mg£300.00
Quantity:
PSI-40-311-0.02mg0.02mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Soluble Fas Receptor recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble Fas Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°

Documents

Further Information

Additional Names:
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, APT1, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen
Background:
Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and 145 amino acid cytoplasmic domain. Recombinant human soluble Fas (sFas Receptor) is a 157 amino acid polypeptide (17.6 kDa) corresponding to the TNFR homologous cysteine rich extracellular domain Fas.
Biological Activity:
The ED50 was Biological activity was determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10 - 15 μg/mL in the presence of 2 ng/mL of hFasL.
NCBI Gene ID #:
355
NCBI Official Name:
Fas cell surface death receptor
NCBI Official Symbol:
FAS
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000034.1
Protein GI Number:
4507583
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P25445