Soluble TNF Receptor Type II Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-304-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-304-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Soluble TNF Receptor Type II recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble TNF Receptor Type II is stable for at least 3 months when stored in working aliquots with a carrier pr
Documents
Further Information
Additional Names:
p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2
Background:
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein.
Biological Activity:
Biological activity was determined by its inhibitory effect of the TNF - a mediated cytotoxicity in murine L - 929 cells. The ED50 for this effect in the presence of 0.25 ng/mL of recombinant human TNF - a, is 0.125 μg/mL.
NCBI Gene ID #:
7133
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 1B
NCBI Official Symbol:
TNFRSF1B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001057.1
Protein GI Number:
4507577
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P20333