CDNF Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-550-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-550-0.025mg | 0.025mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized CDNF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted CDNF stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing C
Documents
Further Information
Additional Names:
ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1
Background:
CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
441549
NCBI Official Name:
cerebral dopamine neurotrophic factor
NCBI Official Symbol:
CDNF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001025125.2
Protein GI Number:
82880674
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q49AH0