p16-INK4a-TAT Recombinant Protein

ProSci
Product Code: PSI-40-527
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-527-0.005mg0.005mg£300.00
Quantity:
PSI-40-527-0.025mg0.025mg£428.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized p16-INK4a-TAT recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted p16-INK4a-TAT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with an

Documents

Further Information

Additional Names:
ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A
Background:
p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. P16-INK4a and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human p16-INK4a-TAT expressed in E. coli is a 18 kDa protein containing 167 amino-acid residues, including the 156 residues of full-length p16-INK4a and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR).
Biological Activity:
Endotoxin level is less than 0.1 ng per ug (1EU/μg).
NCBI Gene ID #:
1029
NCBI Official Name:
cyclin-dependent kinase inhibitor 2A
NCBI Official Symbol:
CDKN2A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000068.1
Protein GI Number:
4502749
Purity:
Greater than or equal to 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P42771