Soluble RANK Receptor Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-300-0.02mg | 0.02mg | £300.00 |
Quantity:
| PSI-40-300-0.1mg | 0.1mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized Soluble RANK Receptor recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble RANK Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20&d
Documents
Further Information
Additional Names:
FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1, Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor
Background:
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na?ve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).
Biological Activity:
Biological activity was determined by its ability to suppress the production of IFN - gamma from human PBMCs.
NCBI Gene ID #:
8792
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NCBI Official Symbol:
TNFRSF11A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001257878.1
Protein GI Number:
401015111
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q9Y6Q6