GDF-3 Recombinant Protein

ProSci
Product Code: PSI-40-592
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-40-592-0.02mg0.02mg£481.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized GDF-3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDF-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos

Documents

Further Information

Additional Names:
KFS3, MCOP7, MCOPCB6GDF-3
Background:
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
Biological Activity:
Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/mL.
NCBI Gene ID #:
9573
NCBI Official Name:
growth differentiation factor 3
NCBI Official Symbol:
GDF3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_065685.1
Protein GI Number:
10190670
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q9NR23