TGF-Beta3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-574-0.01mg | 0.01mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized TGF-Beta3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TGF-Beta3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein,
Documents
Further Information
Additional Names:
ARVD, RNHF, ARVD1, TGF-beta3, Transforming growth factor beta-3, TGF-beta-3
Background:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Manufactured using all non-animal reagents.
Biological Activity:
Biological activity was determined by TGF-β3?s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥2 x 107 units/mg. Endotoxin level is less than 0.1 ng per μg of TGF-β3 (1EU/μg).
NCBI Gene ID #:
7043
NCBI Official Name:
transforming growth factor, beta 3
NCBI Official Symbol:
TGFB3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003230.1
Protein GI Number:
4507465
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P10600